Chromodomain-helicase-DNA-binding protein 6 (CHD-6) (EC 3.6.4.12) (ATP-dependent helicase CHD6) (Radiation-induced gene B protein)
1_MKMKI 6_ QKKEK 11_ QLSNL 16_ KVLNH 21_ SPMSD 26_ ASVNF 31_ DYKSP 36_ SPFDC 41_ STDQE 46_ EKIED 51_ VASHC 56_ LPQKD 61_ LYTAE 66_ EEAAT 71_ LFPRK 76_ MTSHN 81_ GMEDS 86_ GGGGT 91_ GVKKK 96_ RKKKE 101_ PGDQE 106_ GAAKG 111_ SKDRE 116_ PKPKR 121_ KREPK 126_ EPKEP 131_ RKAKE 136_ PKKAK 141_ EHKEP 146_ KQKDG 151_ AKKAR 156_ KPREA 161_ SGTKE 166_ AKEKR 171_ SCTDS 176_ AARTK 181_ SRKAS 186_ KEQGP 191_ TPVEK 196_ KKKGK 201_ RKSET 206_ TVESL 211_ ELDQG 216_ LTNPS 221_ LRSPE 226_ ESTES 231_ TDSQK 236_ RRSGR 241_ QVKRR 246_ KYNED 251_ LDFKV 256_ VDDDG 261_ ETIAV 266_ LGAGR 271_ TSALS 276_ ASTLA 281_ WQAEE 286_ PPEDD 291_ ANIIE 296_ KILAS 301_ KTVQE 306_ VHPGE 311_ PPFDL 316_ ELFYV 321_ KYRNF 326_ SYLHC 331_ KWATM 336_ EELEK 341_ DPRIA 346_ QKIKR 351_ FRNKQ 356_ AQMKH 361_ IFTEP 366_ DEDLF 371_ NPDYV 376_ EVDRI 381_ LEVAH 386_ TKDAE 391_ TGEEV 396_ THYLV 401_ KWCSL 406_ PYEES 411_ TWELE 416_ EDVDP 421_ AKVKE 426_ FESLQ 431_ VLPEI 436_ KHVER 441_ PASDS 446_ WQKLE 451_ KSREY 456_ KNSNQ 461_ LREYQ 466_ LEGMN 471_ WLLFN 476_ WYNRK 481_ NCILA 486_ DEMGL 491_ GKTIQ 496_ SITFL 501_ SEIFL 506_ RGIHG 511_ PFLII 516_ APLST 521_ ITNWE 526_ REFRT 531_ WTEMN 536_ AIVYH 541_ GSQIS 546_ RQMIQ 551_ QYEMV 556_ YRDAQ 561_ GNPLS 566_ GVFKF 571_ HVVIT 576_ TFEMI 581_ LADCP 586_ ELKKI 591_ HWSCV 596_ IIDEA 601_ HRLKN 606_ RNCKL 611_ LEGLK 616_ LMALE 621_ HKVLL 626_ TGTPL 631_ QNSVE 636_ ELFSL 641_ LNFLE 646_ PSQFP 651_ SETAF 656_ LEEFG 661_ DLKTE 666_ EQVKK 671_ LQSIL 676_ KPMML 681_ RRLKD 686_ DVEKN 691_ LAPKQ 696_ ETIIE 701_ VELTN 706_ IQKKY 711_ YRAIL 716_ EKNFS 721_ FLTKG 726_ ANQHN 731_ MPNLI 736_ NTMME 741_ LRKCC 746_ NHPYL 751_ INGAE 756_ EKILE 761_ DFRKT 766_ HSPDA 771_ PDFQL 776_ QAMIQ 781_ AAGKL 786_ VLIDK 791_ LLPKL 796_ IAGGH 801_ KVLIF 806_ SQMVR 811_ CLDIL 816_ EDYLI 821_ QRRYT 826_ YERID 831_ GRVRG 836_ NLRQA 841_ AIDRF 846_ CKPDS 851_ DRFVF 856_ LLCTR 861_ AGGLG 866_ INLTA 871_ ADTCI 876_ IFDSD 881_ WNPQN 886_ DLQAQ 891_ ARCHR 896_ IGQSK 901_ AVKVY 906_ RLITR 911_ NSYER 916_ EMFDK 921_ ASLKL 926_ GLDKA 931_ VLQDI 936_ NRKGG 941_ TNGVQ 946_ QLSKM 951_ EVEDL 956_ LRKGA 961_ YGALM 966_ DEEDE 971_ GSKFC 976_ EEDID 981_ QILQR 986_ RTHTI 991_ TIQSE 996_ GKGST 1001_ FAKAS 1006_ FVASG 1011_ NRTDI 1016_ SLDDP 1021_ NFWQK 1026_ WAKIA 1031_ ELDTE 1036_ AKNEK 1041_ ESLVI 1046_ DRPRV 1051_ RKQTK 1056_ HYNSF 1061_ EEDEL 1066_ MEFSE 1071_ LDSDS 1076_ DERPT 1081_ RSRRL 1086_ NDKAR 1091_ RYLRA 1096_ ECFRV 1101_ EKNLL 1106_ IFGWG 1111_ RWKDI 1116_ LTHGR 1121_ FKWHL 1126_ NEKDM 1131_ EMICR 1136_ ALLVY 1141_ CVKHY 1146_ KGDEK 1151_ IKSFI 1156_ WELIT 1161_ PTKDG 1166_ QAQTL 1171_ QNHSG 1176_ LSAPV 1181_ PRGRK 1186_ GKKTK 1191_ NQLLI 1196_ PELKD 1201_ ADWLA 1206_ TCNPE 1211_ VVLHD 1216_ DGYKK 1221_ HLKQH 1226_ CNKVL 1231_ LRVRM 1236_ LYYLK 1241_ AEILG 1246_ EAAEK 1251_ AFEGS 1256_ PAREL 1261_ DVPLP 1266_ DIDYM 1271_ EIPVD 1276_ WWDAE 1281_ ADKSL 1286_ LIGVF 1291_ KHGYE 1296_ RYNAM 1301_ RADPA 1306_ LCFLE 1311_ KVGMP 1316_ DEKSL 1321_ SAEQG 1326_ VTDGT 1331_ SDIPE 1336_ RGNTD 1341_ KEDNA 1346_ EDKVD 1351_ GLQKQ 1356_ TESSS 1361_ DGGDG 1366_ VFSEK 1371_ KDDSR 1376_ AAQDG 1381_ SDPDK 1386_ SPWPV 1391_ SSALT 1396_ ARLRR 1401_ LVTVY 1406_ QRCNR 1411_ KELCR 1416_ PEILG 1421_ PGNQG 1426_ YWVQE 1431_ EMFRR 1436_ TSEMD 1441_ LINKE 1446_ AQKRW 1451_ TRREQ 1456_ ADFYR 1461_ TVSSF 1466_ GVVYD 1471_ QEKKT 1476_ FDWTQ 1481_ FRIIS 1486_ RLDKK 1491_ SDESL 1496_ EQYFY 1501_ SFVAM 1506_ CRNVC 1511_ RLPTW 1516_ KDGGP 1521_ PDTTI 1526_ YVEPI 1531_ TEERA 1536_ ARTLY 1541_ RIELL 1546_ RKVRE 1551_ QVLKC 1556_ PQLHE 1561_ RLQLC 1566_ RPSLY 1571_ LPVWW 1576_ ECGKH 1581_ DRDLL 1586_ IGTAK 1591_ HGLNR 1596_ TDCYI 1601_ MNDPQ 1606_ LSFLD 1611_ AYRNY 1616_ AQHKR 1621_ SGTQA 1626_ PGNLC 1631_ CLYQT 1636_ NSKLY 1641_ ESLTY 1646_ SQMSR 1651_ TSESL 1656_ ENEPE 1661_ NLVRV 1666_ ESRDD 1671_ HLSLP 1676_ DVTCE 1681_ NFISK 1686_ VQDVI 1691_ SINHD 1696_ ESLLP 1701_ ESLES 1706_ MMYGK 1711_ KVLSQ 1716_ EPSSF 1721_ QESPS 1726_ TNTES 1731_ RKDVI 1736_ TISIS 1741_ KDGNC 1746_ QSGGP 1751_ EAEIA 1756_ SGPTF 1761_ MGSLE 1766_ AGGVA 1771_ QANIK 1776_ NGKHL 1781_ LMSIS 1786_ KEGEL 1791_ CCSEA 1796_ GQRPE 1801_ NIGQL 1806_ EAKCL 1811_ ASPSL 1816_ NPGNE 1821_ SGFVD 1826_ MCSLS 1831_ VCDSK 1836_ RNLSS 1841_ DQQLI 1846_ DLLEN 1851_ KSLES 1856_ KLILS 1861_ QNHSD 1866_ EEEEE 1871_ EENEE 1876_ ENLAM 1881_ AVGMG 1886_ ERPEV 1891_ LHLTE 1896_ PTTNI 1901_ SREKN 1906_ QGFQD 1911_ ETKKG 1916_ SLEVA 1921_ NQTPG 1926_ LQRAF 1931_ PAPAA 1936_ CQCHC 1941_ KHMER 1946_ WMHGL 1951_ ENDEF 1956_ EIEKP 1961_ KAYIP 1966_ DLFKS 1971_ KTNTI 1976_ AMEGE 1981_ PTAIP 1986_ SQPFK 1991_ VKHEL 1996_ LKEPW 2001_ KESAE 2006_ GQNVF 2011_ PTYPL 2016_ EGSEL 2021_ KSEDM 2026_ DFENK 2031_ DDYDR 2036_ DGNCH 2041_ SQDYP 2046_ GKYSE 2051_ EESKS 2056_ STSGI 2061_ TGDIG 2066_ DELQE 2071_ ARAPT 2076_ IAQLL 2081_ QEKTL 2086_ YSFSE 2091_ WPKDR 2096_ VIINR 2101_ LDNIC 2106_ HVVLK 2111_ GKWPS 2116_ SQQYE 2121_ PSGTL 2126_ PTPVL 2131_ TSSAG 2136_ SRTSL 2141_ SEPEA 2146_ AEHSF 2151_ SNGAA 2156_ LAAQI 2161_ HKESF 2166_ LAPVF 2171_ TKDEQ 2176_ KHRRP 2181_ YEFEV 2186_ ERDAK 2191_ ARGLE 2196_ QFSAT 2201_ HGHTP 2206_ IILNG 2211_ WHGES 2216_ AMDLS 2221_ CSSEG 2226_ SPGAT 2231_ SPFPV 2236_ SASTP 2241_ KIGAI 2246_ SSLQG 2251_ ALGMD 2256_ LSGIL 2261_ QAGLI 2266_ HPVTG 2271_ QIVNG 2276_ SLRRD 2281_ DAATR 2286_ RRRGR 2291_ RKHVE 2296_ GGMDL 2301_ IFLKE 2306_ QTLQA 2311_ GILEV 2316_ HEDPG 2321_ QATLS 2326_ TTHPE 2331_ GPGPA 2336_ TSAPE 2341_ PATAA 2346_ SSQAE 2351_ KSIPS 2356_ KSLLD 2361_ WLRQQ 2366_ ADYSL 2371_ EVPGF 2376_ GANFS 2381_ DKPKQ 2386_ RRPRC 2391_ KEPGK 2396_ LDVSS 2401_ LSGEE 2406_ RVPAI 2411_ PKEPG 2416_ LRGFL 2421_ PENKF 2426_ NHTLA 2431_ EPILR 2436_ DTGPR 2441_ RRGRR 2446_ PRSEL 2451_ LKAPS 2456_ IVADS 2461_ PSGMG 2466_ PLFMN 2471_ GLIAG 2476_ MDLVG 2481_ LQNMR 2486_ NMPGI 2491_ PLTGL 2496_ VGFPA 2501_ GFATM 2506_ PTGEE 2511_ VKSTL 2516_ SMLPM 2521_ MLPGM 2526_ AAVPQ 2531_ MFGVG 2536_ GLLSP 2541_ PMATT 2546_ CTSTA 2551_ PASLS 2556_ STTKS 2561_ GTAVT 2566_ EKTAE 2571_ DKPSS 2576_ HDVKT 2581_ DTLAE 2586_ DKPGP 2591_ GPFSD 2596_ QSEPA 2601_ ITTSS 2606_ PVAFN 2611_ PFLIP 2616_ GVSPG 2621_ LIYPS 2626_ MFLSP 2631_ GMGMA 2636_ LPAMQ 2641_ QARHS 2646_ EIVGL 2651_ ESQKR 2656_ KKKKT 2661_ KGDNP 2666_ NSHPE 2671_ PAPSC 2676_ EREPS 2681_ GDENC 2686_ AEPSA 2691_ PLPAE 2696_ REHGA 2701_ QAGEG 2706_ALKDS
1: ATP-dependent chromatin-remodeling factor (PubMed:17027977, PubMed:28533432). Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin; nucleosome disruption requires ATP (PubMed:28533432). Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2
2: (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner