Transient receptor potential cation channel subfamily M member 4 (hTRPM4) (Calcium-activated non-selective cation channel 1) (Long transient receptor potential channel 4) (LTrpC-4) (LTrpC4) (Melastatin-4)
1_MVVPE 6_ KEQSW 11_ IPKIF 16_ KKKTC 21_ TTFIV 26_ DSTDP 31_ GGTLC 36_ QCGRP 41_ RTAHP 46_ AVAME 51_ DAFGA 56_ AVVTV 61_ WDSDA 66_ HTTEK 71_ PTDAY 76_ GELDF 81_ TGAGR 86_ KHSNF 91_ LRLSD 96_ RTDPA 101_ AVYSL 106_ VTRTW 111_ GFRAP 116_ NLVVS 121_ VLGGS 126_ GGPVL 131_ QTWLQ 136_ DLLRR 141_ GLVRA 146_ AQSTG 151_ AWIVT 156_ GGLHT 161_ GIGRH 166_ VGVAV 171_ RDHQM 176_ ASTGG 181_ TKVVA 186_ MGVAP 191_ WGVVR 196_ NRDTL 201_ INPKG 206_ SFPAR 211_ YRWRG 216_ DPEDG 221_ VQFPL 226_ DYNYS 231_ AFFLV 236_ DDGTH 241_ GCLGG 246_ ENRFR 251_ LRLES 256_ YISQQ 261_ KTGVG 266_ GTGID 271_ IPVLL 276_ LLIDG 281_ DEKML 286_ TRIEN 291_ ATQAQ 296_ LPCLL 301_ VAGSG 306_ GAADC 311_ LAETL 316_ EDTLA 321_ PGSGG 326_ ARQGE 331_ ARDRI 336_ RRFFP 341_ KGDLE 346_ VLQAQ 351_ VERIM 356_ TRKEL 361_ LTVYS 366_ SEDGS 371_ EEFET 376_ IVLKA 381_ LVKAC 386_ GSSEA 391_ SAYLD 396_ ELRLA 401_ VAWNR 406_ VDIAQ 411_ SELFR 416_ GDIQW 421_ RSFHL 426_ EASLM 431_ DALLN 436_ DRPEF 441_ VRLLI 446_ SHGLS 451_ LGHFL 456_ TPMRL 461_ AQLYS 466_ AAPSN 471_ SLIRN 476_ LLDQA 481_ SHSAG 486_ TKAPA 491_ LKGGA 496_ AELRP 501_ PDVGH 506_ VLRML 511_ LGKMC 516_ APRYP 521_ SGGAW 526_ DPHPG 531_ QGFGE 536_ SMYLL 541_ SDKAT 546_ SPLSL 551_ DAGLG 556_ QAPWS 561_ DLLLW 566_ ALLLN 571_ RAQMA 576_ MYFWE 581_ MGSNA 586_ VSSAL 591_ GACLL 596_ LRVMA 601_ RLEPD 606_ AEEAA 611_ RRKDL 616_ AFKFE 621_ GMGVD 626_ LFGEC 631_ YRSSE 636_ VRAAR 641_ LLLRR 646_ CPLWG 651_ DATCL 656_ QLAMQ 661_ ADARA 666_ FFAQD 671_ GVQSL 676_ LTQKW 681_ WGDMA 686_ STTPI 691_ WALVL 696_ AFFCP 701_ PLIYT 706_ RLITF 711_ RKSEE 716_ EPTRE 721_ ELEFD 726_ MDSVI 731_ NGEGP 736_ VGTAD 741_ PAEKT 746_ PLGVP 751_ RQSGR 756_ PGCCG 761_ GRCGG 766_ RRCLR 771_ RWFHF 776_ WGAPV 781_ TIFMG 786_ NVVSY 791_ LLFLL 796_ LFSRV 801_ LLVDF 806_ QPAPP 811_ GSLEL 816_ LLYFW 821_ AFTLL 826_ CEELR 831_ QGLSG 836_ GGGSL 841_ ASGGP 846_ GPGHA 851_ SLSQR 856_ LRLYL 861_ ADSWN 866_ QCDLV 871_ ALTCF 876_ LLGVG 881_ CRLTP 886_ GLYHL 891_ GRTVL 896_ CIDFM 901_ VFTVR 906_ LLHIF 911_ TVNKQ 916_ LGPKI 921_ VIVSK 926_ MMKDV 931_ FFFLF 936_ FLGVW 941_ LVAYG 946_ VATEG 951_ LLRPR 956_ DSDFP 961_ SILRR 966_ VFYRP 971_ YLQIF 976_ GQIPQ 981_ EDMDV 986_ ALMEH 991_ SNCSS 996_ EPGFW 1001_ AHPPG 1006_ AQAGT 1011_ CVSQY 1016_ ANWLV 1021_ VLLLV 1026_ IFLLV 1031_ ANILL 1036_ VNLLI 1041_ AMFSY 1046_ TFGKV 1051_ QGNSD 1056_ LYWKA 1061_ QRYRL 1066_ IREFH 1071_ SRPAL 1076_ APPFI 1081_ VISHL 1086_ RLLLR 1091_ QLCRR 1096_ PRSPQ 1101_ PSSPA 1106_ LEHFR 1111_ VYLSK 1116_ EAERK 1121_ LLTWE 1126_ SVHKE 1131_ NFLLA 1136_ RARDK 1141_ RESDS 1146_ ERLKR 1151_ TSQKV 1156_ DLALK 1161_ QLGHI 1166_ REYEQ 1171_ RLKVL 1176_ EREVQ 1181_ QCSRV 1186_ LGWVA 1191_ EALSR 1196_ SALLP 1201_ PGGPP 1206_PPDLP
1: Calcium-activated selective cation channel that mediates membrane depolarization (PubMed:12015988, PubMed:12842017, PubMed:29211723, PubMed:30528822). While it is activated by increase in intracellular Ca(2+), it is impermeable to it (PubMed:12015988). Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane (PubMed:12015988). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (PubMed:30528822)
2: Lacks channel activity