Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1)
1_MSSGA 6_ KEGGG 11_ GSPAY 16_ HLPHP 21_ HPHPP 26_ QHAQY 31_ VGPYR 36_ LEKTL 41_ GKGQT 46_ GLVKL 51_ GVHCI 56_ TGQKV 61_ AIKIV 66_ NREKL 71_ SESVL 76_ MKVER 81_ EIAIL 86_ KLIEH 91_ PHVLK 96_ LHDVY 101_ ENKKY 106_ LYLVL 111_ EHVSG 116_ GELFD 121_ YLVKK 126_ GRLTP 131_ KEARK 136_ FFRQI 141_ VSALD 146_ FCHSY 151_ SICHR 156_ DLKPE 161_ NLLLD 166_ EKNNI 171_ RIADF 176_ GMASL 181_ QVGDS 186_ LLETS 191_ CGSPH 196_ YACPE 201_ VIKGE 206_ KYDGR 211_ RADMW 216_ SCGVI 221_ LFALL 226_ VGALP 231_ FDDDN 236_ LRQLL 241_ EKVKR 246_ GVFHM 251_ PHFIP 256_ PDCQS 261_ LLRGM 266_ IEVEP 271_ EKRLS 276_ LEQIQ 281_ KHPWY 286_ LGGKH 291_ EPDPC 296_ LEPAP 301_ GRRVA 306_ MRSLP 311_ SNGEL 316_ DPDVL 321_ ESMAS 326_ LGCFR 331_ DRERL 336_ HRELR 341_ SEEEN 346_ QEKMI 351_ YYLLL 356_ DRKER 361_ YPSCE 366_ DQDLP 371_ PRNDV 376_ DPPRK 381_ RVDSP 386_ MLSRH 391_ GKRRP 396_ ERKSM 401_ EVLSI 406_ TDAGG 411_ GGSPV 416_ PTRRA 421_ LEMAQ 426_ HSQRS 431_ RSVSG 436_ ASTGL 441_ SSSPL 446_ SSPRS 451_ PVFSF 456_ SPEPG 461_ AGDEA 466_ RGGGS 471_ PTSKT 476_ QTLPS 481_ RGPRG 486_ GGAGE 491_ QPPPP 496_ SARST 501_ PLPGP 506_ PGSPR 511_ SSGGT 516_ PLHSP 521_ LHTPR 526_ ASPTG 531_ TPGTT 536_ PPPSP 541_ GGGVG 546_ GAAWR 551_ SRLNS 556_ IRNSF 561_ LGSPR 566_ FHRRK 571_ MQVPT 576_ AEEMS 581_ SLTPE 586_ SSPEL 591_ AKRSW 596_ FGNFI 601_ SLDKE 606_ EQIFL 611_ VLKDK 616_ PLSSI 621_ KADIV 626_ HAFLS 631_ IPSLS 636_ HSVLS 641_ QTSFR 646_ AEYKA 651_ SGGPS 656_ VFQKP 661_ VRFQV 666_ DISSS 671_ EGPEP 676_ SPRRD 681_ GSGGG 686_ GIYSV 691_ TFTLI 696_ SGPSR 701_ RFKRV 706_ VETIQ 711_ AQLLS 716_ THDQP 721_ SVQAL 726_ ADEKN 731_ GAQTR 736_ PAGAP 741_ PRSLQ 746_ PPPGR 751_ PDPEL 756_ SSSPR 761_ RGPPK 766_ DKKLL 771_ATNGT
1: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C