Mucolipin-3 (Transient receptor potential channel mucolipin 3) (TRPML3)
1_MADPE 6_ VVVSS 11_ CSSHE 16_ EENRC 21_ NFNQQ 26_ TSPSE 31_ ELLLE 36_ DQMRR 41_ KLKFF 46_ FMNPC 51_ EKFWA 56_ RGRKP 61_ WKLAI 66_ QILKI 71_ AMVTI 76_ QLVLF 81_ GLSNQ 86_ MVVAF 91_ KEENT 96_ IAFKH 101_ LFLKG 106_ YMDRM 111_ DDTYA 116_ VYTQS 121_ DVYDQ 126_ LIFAV 131_ NQYLQ 136_ LYNVS 141_ VGNHA 146_ YENKG 151_ TKQSA 156_ MAICQ 161_ HFYKR 166_ GNIYP 171_ GNDTF 176_ DIDPE 181_ IETEC 186_ FFVEP 191_ DEPFH 196_ IGTPA 201_ ENKLN 206_ LTLDF 211_ HRLLT 216_ VELQF 221_ KLKAI 226_ NLQTV 231_ RHQEL 236_ PDCYD 241_ FTLTI 246_ TFDNK 251_ AHSGR 256_ IKISL 261_ DNDIS 266_ IRECK 271_ DWHVS 276_ GSIQK 281_ NTHYM 286_ MIFDA 291_ FVILT 296_ CLVSL 301_ ILCIR 306_ SVIRG 311_ LQLQQ 316_ EFVNF 321_ FLLHY 326_ KKEVS 331_ VSDQM 336_ EFVNG 341_ WYIMI 346_ IISDI 351_ LTIIG 356_ SILKM 361_ EIQAK 366_ SLTSY 371_ DVCSI 376_ LLGTS 381_ TMLVW 386_ LGVIR 391_ YLGFF 396_ AKYNL 401_ LILTL 406_ QAALP 411_ NVIRF 416_ CCCAA 421_ MIYLG 426_ YCFCG 431_ WIVLG 436_ PYHDK 441_ FRSLN 446_ MVSEC 451_ LFSLI 456_ NGDDM 461_ FATFA 466_ KMQQK 471_ SYLVW 476_ LFSRI 481_ YLYSF 486_ ISLFI 491_ YMILS 496_ LFIAL 501_ ITDTY 506_ ETIKQ 511_ YQQDG 516_ FPETE 521_ LRTFI 526_ SECKD 531_ LPNSG 536_ KYRLE 541_ DDPPV 546_SLFCC
1: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Also permeable to Mg(2+), Na(+) and K(+) (By similarity). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3 (PubMed:23469151)