RAS guanyl-releasing protein 4
1_MNRKD 6_ SKRKS 11_ HQECT 16_ GKIGG 21_ RGRPR 26_ QVRRH 31_ KTCPS 36_ PREIS 41_ KVMAS 46_ MNLGL 51_ LSEGG 56_ CSEDE 61_ LLEKC 66_ IQSFD 71_ SAGSL 76_ CHEDH 81_ MLNMV 86_ LAMHS 91_ WVLPS 96_ ADLAA 101_ RLLTS 106_ YQKAT 111_ GDTQE 116_ LRRLQ 121_ ICHLV 126_ RYWLM 131_ RHPEV 136_ MHQDP 141_ QLEEV 146_ IGRFW 151_ ATVAR 156_ EGNSA 161_ QRRLG 166_ DSSDL 171_ LSPGG 176_ PGPPL 181_ PMSSP 186_ GLGKK 191_ RKVSL 196_ LFDHL 201_ ETGEL 206_ AQHLT 211_ YLEFR 216_ SFQAI 221_ TPQDL 226_ RSYVL 231_ QGSVR 236_ GCPAL 241_ EGSVG 246_ LSNSV 251_ SRWVQ 256_ VMVLS 261_ RPGPL 266_ QRAQV 271_ LDKFI 276_ HVAQR 281_ LHQLQ 286_ NFNTL 291_ MAVTG 296_ GLCHS 301_ AISRL 306_ KDSHA 311_ HLSPD 316_ STKAL 321_ LELTE 326_ LLASH 331_ NNYAR 336_ YRRTW 341_ AGCAG 346_ FRLPV 351_ LGVHL 356_ KDLVS 361_ LHEAQ 366_ PDRLP 371_ DGRLH 376_ LPKLN 381_ NLYLR 386_ LQELV 391_ ALQGQ 396_ HPPCS 401_ ANEDL 406_ LHLLT 411_ LSLDL 416_ FYTED 421_ EIYEL 426_ SYARE 431_ PRCPK 436_ SLPPS 441_ PFNAP 446_ LVVEW 451_ APGVT 456_ PKPDR 461_ VTLGR 466_ HVEQL 471_ VESVF 476_ KNYDP 481_ EGRGT 486_ ISQED 491_ FERLS 496_ GNFPF 501_ ACHGL 506_ HPPPR 511_ QGRGS 516_ FSREE 521_ LTGYL 526_ LRASA 531_ ICSKL 536_ GLAFL 541_ HTFHE 546_ VTFRK 551_ PTFCD 556_ SCSGF 561_ LWGVT 566_ KQGYR 571_ CRECG 576_ LCCHK 581_ HCRDQ 586_ VKVEC 591_ KKRPG 596_ AKGDA 601_ GPPGA 606_ PVPST 611_ PAPHA 616_ SCGSE 621_ ENHSY 626_ TLSLE 631_ PETGC 636_ QLRHA 641_ WTQTE 646_ SPHPS 651_ WETDT 656_ VPCPV 661_ MDPPS 666_TASSK
1: Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses (By similarity). In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells (By similarity). May function in mast cell differentiation (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells (By similarity)