Helicase POLQ-like (EC 3.6.4.12) (Mus308-like helicase) (POLQ-like helicase)
1_MDECG 6_ SRIRR 11_ RVSLP 16_ KRNRP 21_ SLGCI 26_ FGAPT 31_ AAELV 36_ PGDEG 41_ KEEEE 46_ MVAEN 51_ RRRKT 56_ AGVLP 61_ VEVQP 66_ LLLSD 71_ SPECL 76_ VLGGG 81_ DTNPD 86_ LLRHM 91_ PTDRG 96_ VGDQP 101_ NDSEV 106_ DMFGD 111_ YDSFT 116_ ENSFI 121_ AQVDD 126_ LEQKY 131_ MQLPE 136_ HKKHA 141_ TDFAT 146_ ENLCS 151_ ESIKN 156_ KLSIT 161_ TIGNL 166_ TELQT 171_ DKHTE 176_ NQSGY 181_ EGVTI 186_ EPGAD 191_ LLYDV 196_ PSSQA 201_ IYFEN 206_ LQNSS 211_ NDLGD 216_ HSMKE 221_ RDWKS 226_ SSHNT 231_ VNEEL 236_ PHNCI 241_ EQPQQ 246_ NDESS 251_ SKVRT 256_ SSDMN 261_ RRKSI 266_ KDHLK 271_ NAMTG 276_ NAKAQ 281_ TPIFS 286_ RSKQL 291_ KDTLL 296_ SEEIN 301_ VAKKT 306_ VESSS 311_ NDLGP 316_ FYSLP 321_ SKVRD 326_ LYAQF 331_ KGIEK 336_ LYEWQ 341_ HTCLT 346_ LNSVQ 351_ ERKNL 356_ IYSLP 361_ TSGGK 366_ TLVAE 371_ ILMLQ 376_ ELLCC 381_ RKDVL 386_ MILPY 391_ VAIVQ 396_ EKISG 401_ LSSFG 406_ IELGF 411_ FVEEY 416_ AGSKG 421_ RFPPT 426_ KRREK 431_ KSLYI 436_ ATIEK 441_ GHSLV 446_ NSLIE 451_ TGRID 456_ SLGLV 461_ VVDEL 466_ HMIGE 471_ GSRGA 476_ TLEMT 481_ LAKIL 486_ YTSKT 491_ TQIIG 496_ MSATL 501_ NNVED 506_ LQKFL 511_ QAEYY 516_ TSQFR 521_ PVELK 526_ EYLKI 531_ NDTIY 536_ EVDSK 541_ AENGM 546_ TFSRL 551_ LNYKY 556_ SDTLK 561_ KMDPD 566_ HLVAL 571_ VTEVI 576_ PNYSC 581_ LVFCP 586_ SKKNC 591_ ENVAE 596_ MICKF 601_ LSKEY 606_ LKHKE 611_ KEKCE 616_ VIKNL 621_ KNIGN 626_ GNLCP 631_ VLKRT 636_ IPFGV 641_ AYHHS 646_ GLTSD 651_ ERKLL 656_ EEAYS 661_ TGVLC 666_ LFTCT 671_ STLAA 676_ GVNLP 681_ ARRVI 686_ LRAPY 691_ VAKEF 696_ LKRNQ 701_ YKQMI 706_ GRAGR 711_ AGIDT 716_ IGESI 721_ LILQE 726_ KDKQQ 731_ VLELI 736_ TKPLE 741_ NCYSH 746_ LVQEF 751_ TKGIQ 756_ TLFLS 761_ LIGLK 766_ IATNL 771_ DDIYH 776_ FMNGT 781_ FFGVQ 786_ QKVLL 791_ KEKSL 796_ WEITV 801_ ESLRY 806_ LTEKG 811_ LLQKD 816_ TIYKS 821_ EEEVQ 826_ YNFHI 831_ TKLGR 836_ ASFKG 841_ TIDLA 846_ YCDIL 851_ YRDLK 856_ KGLEG 861_ LVLES 866_ LLHLI 871_ YLTTP 876_ YDLVS 881_ QCNPD 886_ WMIYF 891_ RQFSQ 896_ LSPAE 901_ QNVAA 906_ ILGVS 911_ ESFIG 916_ KKASG 921_ QAIGK 926_ KVDKN 931_ VVNRL 936_ YLSFV 941_ LYTLL 946_ KETNI 951_ WTVSE 956_ KFNMP 961_ RGYIQ 966_ NLLTG 971_ TASFS 976_ SCVLH 981_ FCEEL 986_ EEFWV 991_ YRALL 996_ VELTK 1001_ KLTYC 1006_ VKAEL 1011_ IPLME 1016_ VTGVL 1021_ EGRAK 1026_ QLYSA 1031_ GYKSL 1036_ MHLAN 1041_ ANPEV 1046_ LVRTI 1051_ DHLSR 1056_ RQAKQ 1061_ IVSSA 1066_ KMLLH 1071_ EKAEA 1076_ LQEEV 1081_ EELLR 1086_ LPSDF 1091_ PGAVA 1096_SSTDK
1: Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair (PubMed:11751861, PubMed:19995904, PubMed:21398521, PubMed:24005041, PubMed:24005565, PubMed:34316696, PubMed:34937945). Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (PubMed:34937945). Possesses both DNA unwinding and annealing activities (PubMed:34937945). Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA (PubMed:34937945). Efficiently unwinds substrates containing 3' overhangs or a D-loop (PubMed:21398521, PubMed:34937945). In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing (PubMed:34937945). Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences (PubMed:34316696, PubMed:34937945)