Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC-1 subunit 5) (Protein Muted homolog)
1_MSGGG 6_ TETPV 11_ GCEAA 16_ PGGGS 21_ KKRDS 26_ LGTAG 31_ SAHLI 36_ IKDLG 41_ EIHSR 46_ LLDHR 51_ PVIQG 56_ ETRYF 61_ VKEFE 66_ EKRGL 71_ REMRV 76_ LENLK 81_ NMIHE 86_ TNEHT 91_ LPKCR 96_ DTMRD 101_ SLSQV 106_ LQRLQ 111_ AANDS 116_ VCRLQ 121_ QREQE 126_ RKKIH 131_ SDHLV 136_ ASEKQ 141_ HMLQW 146_ DNFMK 151_ EQPNK 156_ RAEVD 161_ EEHRK 166_ AMERL 171_ KEQYA 176_ EMEKD 181_LAKFS
1: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:32565547). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking