Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.12) (ATP-dependent helicase CHD5)
1_MRGPV 6_ GTEEE 11_ LPRLF 16_ AEEME 21_ NEDEM 26_ SEEED 31_ GGLEA 36_ FDDFF 41_ PVEPV 46_ SLPKK 51_ KKPKK 56_ LKENK 61_ CKGKR 66_ KKKEG 71_ SNDEL 76_ SENEE 81_ DLEEK 86_ SESEG 91_ SDYSP 96_ NKKKK 101_ KKLKD 106_ KKEKK 111_ AKRKK 116_ KDEDE 121_ DDNDD 126_ GCLKE 131_ PKSSG 136_ QLMAE 141_ WGLDD 146_ VDYLF 151_ SEEDY 156_ HTLTN 161_ YKAFS 166_ QFLRP 171_ LIAKK 176_ NPKIP 181_ MSKMM 186_ TVLGA 191_ KWREF 196_ SANNP 201_ FKGSS 206_ AAAAA 211_ AAVAA 216_ AVETV 221_ TISPP 226_ LAVSP 231_ PQVPQ 236_ PVPIR 241_ KAKTK 246_ EGKGP 251_ GVRKK 256_ IKGSK 261_ DGKKK 266_ GKGKK 271_ TAGLK 276_ FRFGG 281_ ISNKR 286_ KKGSS 291_ SEEDE 296_ REESD 301_ FDSAS 306_ IHSAS 311_ VRSEC 316_ SAALG 321_ KKSKR 326_ RRKKK 331_ RIDDG 336_ DGYET 341_ DHQDY 346_ CEVCQ 351_ QGGEI 356_ ILCDT 361_ CPRAY 366_ HLVCL 371_ DPELE 376_ KAPEG 381_ KWSCP 386_ HCEKE 391_ GIQWE 396_ PKDDD 401_ DEEEE 406_ GGCEE 411_ EEDDH 416_ MEFCR 421_ VCKDG 426_ GELLC 431_ CDACP 436_ SSYHL 441_ HCLNP 446_ PLPEI 451_ PNGEW 456_ LCPRC 461_ TCPPL 466_ KGKVQ 471_ RILHW 476_ RWTEP 481_ PAPFM 486_ VGLPG 491_ PDVEP 496_ SLPPP 501_ KPLEG 506_ IPERE 511_ FFVKW 516_ AGLSY 521_ WHCSW 526_ VKELQ 531_ LELYH 536_ TVMYR 541_ NYQRK 546_ NDMDE 551_ PPPFD 556_ YGSGD 561_ EDGKS 566_ EKRKN 571_ KDPLY 576_ AKMEE 581_ RFYRY 586_ GIKPE 591_ WMMIH 596_ RILNH 601_ SFDKK 606_ GDVHY 611_ LIKWK 616_ DLPYD 621_ QCTWE 626_ IDDID 631_ IPYYD 636_ NLKQA 641_ YWGHR 646_ ELMLG 651_ EDTRL 656_ PKRLL 661_ KKGKK 666_ LRDDK 671_ QEKPP 676_ DTPIV 681_ DPTVK 686_ FDKQP 691_ WYIDS 696_ TGGTL 701_ HPYQL 706_ EGLNW 711_ LRFSW 716_ AQGTD 721_ TILAD 726_ EMGLG 731_ KTVQT 736_ IVFLY 741_ SLYKE 746_ GHSKG 751_ PYLVS 756_ APLST 761_ IINWE 766_ REFEM 771_ WAPDF 776_ YVVTY 781_ TGDKE 786_ SRSVI 791_ RENEF 796_ SFEDN 801_ AIRSG 806_ KKVFR 811_ MKKEV 816_ QIKFH 821_ VLLTS 826_ YELIT 831_ IDQAI 836_ LGSIE 841_ WACLV 846_ VDEAH 851_ RLKNN 856_ QSKFF 861_ RVLNS 866_ YKIDY 871_ KLLLT 876_ GTPLQ 881_ NNLEE 886_ LFHLL 891_ NFLTP 896_ ERFNN 901_ LEGFL 906_ EEFAD 911_ ISKED 916_ QIKKL 921_ HDLLG 926_ PHMLR 931_ RLKAD 936_ VFKNM 941_ PAKTE 946_ LIVRV 951_ ELSQM 956_ QKKYY 961_ KFILT 966_ RNFEA 971_ LNSKG 976_ GGNQV 981_ SLLNI 986_ MMDLK 991_ KCCNH 996_ PYLFP 1001_ VAAVE 1006_ APVLP 1011_ NGSYD 1016_ GSSLV 1021_ KSSGK 1026_ LMLLQ 1031_ KMLKK 1036_ LRDEG 1041_ HRVLI 1046_ FSQMT 1051_ KMLDL 1056_ LEDFL 1061_ EYEGY 1066_ KYERI 1071_ DGGIT 1076_ GGLRQ 1081_ EAIDR 1086_ FNAPG 1091_ AQQFC 1096_ FLLST 1101_ RAGGL 1106_ GINLA 1111_ TADTV 1116_ IIYDS 1121_ DWNPH 1126_ NDIQA 1131_ FSRAH 1136_ RIGQN 1141_ KKVMI 1146_ YRFVT 1151_ RASVE 1156_ ERITQ 1161_ VAKRK 1166_ MMLTH 1171_ LVVRP 1176_ GLGSK 1181_ SGSMT 1186_ KQELD 1191_ DILKF 1196_ GTEEL 1201_ FKDDV 1206_ EGMMS 1211_ QGQRP 1216_ VTPIP 1221_ DVQSS 1226_ KGGNL 1231_ AASAK 1236_ KKHGS 1241_ TPPGD 1246_ NKDVE 1251_ DSSVI 1256_ HYDDA 1261_ AISKL 1266_ LDRNQ 1271_ DATDD 1276_ TELQN 1281_ MNEYL 1286_ SSFKV 1291_ AQYVV 1296_ REEDG 1301_ VEEVE 1306_ REIIK 1311_ QEENV 1316_ DPDYW 1321_ EKLLR 1326_ HHYEQ 1331_ QQEDL 1336_ ARNLG 1341_ KGKRI 1346_ RKQVN 1351_ YNDAS 1356_ QEDQE 1361_ WQDEL 1366_ SDNQS 1371_ EYSIG 1376_ SEDED 1381_ EDFEE 1386_ RPEGQ 1391_ SGRRQ 1396_ SRRQL 1401_ KSDRD 1406_ KPLPP 1411_ LLARV 1416_ GGNIE 1421_ VLGFN 1426_ ARQRK 1431_ AFLNA 1436_ IMRWG 1441_ MPPQD 1446_ AFNSH 1451_ WLVRD 1456_ LRGKS 1461_ EKEFR 1466_ AYVSL 1471_ FMRHL 1476_ CEPGA 1481_ DGAET 1486_ FADGV 1491_ PREGL 1496_ SRQHV 1501_ LTRIG 1506_ VMSLV 1511_ RKKVQ 1516_ EFEHV 1521_ NGKYS 1526_ TPDLI 1531_ PEGPE 1536_ GKKSG 1541_ EVISS 1546_ DPNTP 1551_ VPASP 1556_ AHLLP 1561_ APLGL 1566_ PDKME 1571_ AQLGY 1576_ MDEKD 1581_ PGAQK 1586_ PRQPL 1591_ EVQAL 1596_ PAALD 1601_ RVESE 1606_ DKHES 1611_ PASKE 1616_ RAREE 1621_ RPEET 1626_ EKAPP 1631_ SPEQL 1636_ PREEV 1641_ LPEKE 1646_ KILDK 1651_ LELSL 1656_ IHSRG 1661_ DSSEL 1666_ RPDDT 1671_ KAEEK 1676_ EPIET 1681_ QQNGD 1686_ KEEDD 1691_ EGKKE 1696_ DKKGK 1701_ FKFMF 1706_ NIADG 1711_ GFTEL 1716_ HTLWQ 1721_ NEERA 1726_ AVSSG 1731_ KIYDI 1736_ WHRRH 1741_ DYWLL 1746_ AGIVT 1751_ HGYAR 1756_ WQDIQ 1761_ NDPRY 1766_ MILNE 1771_ PFKSE 1776_ VHKGN 1781_ YLEMK 1786_ NKFLA 1791_ RRFKL 1796_ LEQAL 1801_ VIEEQ 1806_ LRRAA 1811_ YLNMT 1816_ QDPNH 1821_ PAMAL 1826_ NARLA 1831_ EVECL 1836_ AESHQ 1841_ HLSKE 1846_ SLAGN 1851_ KPANA 1856_ VLHKV 1861_ LNQLE 1866_ ELLSD 1871_ MKADV 1876_ TRLPS 1881_ MLSRI 1886_ PPVAA 1891_ RLQMS 1896_ ERSIL 1901_ SRLTN 1906_ RAGDP 1911_ TIQQG 1916_ AFGSS 1921_ QMYSN 1926_ NFGPN 1931_ FRGPG 1936_ PGGIV 1941_ NYNQM 1946_PLGPY
1: ATP-dependent chromatin-remodeling factor that binds DNA through histones and regulates gene transcription. May specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. Regulates the expression of genes involved in cell proliferation and differentiation. Downstream activated genes may include CDKN2A that positively regulates the p53/TP53 pathway, which in turn, prevents cell proliferation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa