Transmembrane channel-like protein 2 (Transmembrane cochlear-expressed protein 2)
1_MSHQV 6_ KGLKE 11_ EARGG 16_ VKGRV 21_ KSGSP 26_ HTGDR 31_ LGRRS 36_ SSKRA 41_ LKAEG 46_ TPGRR 51_ GAQRS 56_ QKERA 61_ GGSPS 66_ PGSPR 71_ RKQTG 76_ RRRHR 81_ EELGE 86_ QERGE 91_ AERTC 96_ EGRRK 101_ RDERA 106_ SFQER 111_ TAAPK 116_ REKEI 121_ PRREE 126_ KSKRQ 131_ KKPRS 136_ SSLAS 141_ SASGG 146_ ESLSE 151_ EELAQ 156_ ILEQV 161_ EEKKK 166_ LIATM 171_ RSKPW 176_ PMAKK 181_ LTELR 186_ EAQEF 191_ VEKYE 196_ GALGK 201_ GKGKQ 206_ LYAYK 211_ MLMAK 216_ KWVKF 221_ KRDFD 226_ NFKTQ 231_ CIPWE 236_ MKIKD 241_ IESHF 246_ GSSVA 251_ SYFIF 256_ LRWMY 261_ GVNLV 266_ LFGLI 271_ FGLVI 276_ IPEVL 281_ MGMPY 286_ GSIPR 291_ KTVPR 296_ AEEEK 301_ AMDFS 306_ VLWDF 311_ EGYIK 316_ YSALF 321_ YGYYN 326_ NQRTI 331_ GWLRY 336_ RLPMA 341_ YFMVG 346_ VSVFG 351_ YSLII 356_ VIRSM 361_ ASNTQ 366_ GSTGE 371_ GESDN 376_ FTFSF 381_ KMFTS 386_ WDYLI 391_ GNSET 396_ ADNKY 401_ ASITT 406_ SFKES 411_ IVDEQ 416_ ESNKE 421_ ENIHL 426_ TRFLR 431_ VLANF 436_ LIICC 441_ LCGSG 446_ YLIYF 451_ VVKRS 456_ QQFSK 461_ MQNVS 466_ WYERN 471_ EVEIV 476_ MSLLG 481_ MFCPP 486_ LFETI 491_ AALEN 496_ YHPRT 501_ GLKWQ 506_ LGRIF 511_ ALFLG 516_ NLYTF 521_ LLALM 526_ DDVHL 531_ KLANE 536_ ETIKN 541_ ITHWT 546_ LFNYY 551_ NSSGW 556_ NESVP 561_ RPPLH 566_ PADVP 571_ RGSCW 576_ ETAVG 581_ IEFMR 586_ LTVSD 591_ MLVTY 596_ ITILL 601_ GDFLR 606_ ACFVR 611_ FMNYC 616_ WCWDL 621_ EAGFP 626_ SYAEF 631_ DISGN 636_ VLGLI 641_ FNQGM 646_ IWMGS 651_ FYAPG 656_ LVGIN 661_ VLRLL 666_ TSMYF 671_ QCWAV 676_ MSSNV 681_ PHERV 686_ FKASR 691_ SNNFY 696_ MGLLL 701_ LVLFL 706_ SLLPV 711_ AYTIM 716_ SLPPS 721_ FDCGP 726_ FSGKN 731_ RMYDV 736_ LQETI 741_ ENDFP 746_ TFLGK 751_ IFAFL 756_ ANPGL 761_ IIPAI 766_ LLMFL 771_ AIYYL 776_ NSVSK 781_ SLSRA 786_ NAQLR 791_ KKIQV 796_ LREVE 801_ KSHKS 806_ VKGKA 811_ TARDS 816_ EDTPK 821_ SSSKN 826_ ATQLQ 831_ LTKEE 836_ TTPPS 841_ ASQSQ 846_ AMDKK 851_ AQGPG 856_ TSNSA 861_ SRTTL 866_ PASGH 871_ LPISR 876_ PPGIG 881_ PDSGH 886_ APSQT 891_ HPWRS 896_ ASGKS 901_AQRPP
1: Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (PubMed:11850618). The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located (By similarity). TMC2 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cell transduction current of the mammalian inner ear (By similarity)