Transmembrane channel-like protein 1 (Transmembrane cochlear-expressed protein 1)
1_MSPKK 6_ VQIKV 11_ EEKED 16_ ETEES 21_ SSEEE 26_ EEVED 31_ KLPRR 36_ ESLRP 41_ KRKRT 46_ RDVIN 51_ EDDPE 56_ PEPED 61_ EETRK 66_ AREKE 71_ RRRRL 76_ KRGAE 81_ EEEID 86_ EEELE 91_ RLKAE 96_ LDEKR 101_ QIIAT 106_ VKCKP 111_ WKMEK 116_ KIEVL 121_ KEAKK 126_ FVSEN 131_ EGALG 136_ KGKGK 141_ RWFAF 146_ KMMMA 151_ KKWAK 156_ FLRDF 161_ ENFKA 166_ ACVPW 171_ ENKIK 176_ AIESQ 181_ FGSSV 186_ ASYFL 191_ FLRWM 196_ YGVNM 201_ VLFIL 206_ TFSLI 211_ MLPEY 216_ LWGLP 221_ YGSLP 226_ RKTVP 231_ RAEEA 236_ SAANF 241_ GVLYD 246_ FNGLA 251_ QYSVL 256_ FYGYY 261_ DNKRT 266_ IGWMN 271_ FRLPL 276_ SYFLV 281_ GIMCI 286_ GYSFL 291_ VVLKA 296_ MTKNI 301_ GDDGG 306_ GDDNT 311_ FNFSW 316_ KVFTS 321_ WDYLI 326_ GNPET 331_ ADNKF 336_ NSITM 341_ NFKEA 346_ ITEEK 351_ AAQVE 356_ ENVHL 361_ IRFLR 366_ FLANF 371_ FVFLT 376_ LGGSG 381_ YLIFW 386_ AVKRS 391_ QEFAQ 396_ QDPDT 401_ LGWWE 406_ KNEMN 411_ MVMSL 416_ LGMFC 421_ PTLFD 426_ LFAEL 431_ EDYHP 436_ LIALK 441_ WLLGR 446_ IFALL 451_ LGNLY 456_ VFILA 461_ LMDEI 466_ NNKIE 471_ EEKLV 476_ KANIT 481_ LWEAN 486_ MIKAY 491_ NASFS 496_ ENSTG 501_ PPFFV 506_ HPADV 511_ PRGPC 516_ WETMV 521_ GQEFV 526_ RLTVS 531_ DVLTT 536_ YVTIL 541_ IGDFL 546_ RACFV 551_ RFCNY 556_ CWCWD 561_ LEYGY 566_ PSYTE 571_ FDISG 576_ NVLAL 581_ IFNQG 586_ MIWMG 591_ SFFAP 596_ SLPGI 601_ NILRL 606_ HTSMY 611_ FQCWA 616_ VMCCN 621_ VPEAR 626_ VFKAS 631_ RSNNF 636_ YLGML 641_ LLILF 646_ LSTMP 651_ VLYMI 656_ VSLPP 661_ SFDCG 666_ PFSGK 671_ NRMFE 676_ VIGET 681_ LEHDF 686_ PSWMA 691_ KILRQ 696_ LSNPG 701_ LVIAV 706_ ILVMV 711_ LAIYY 716_ LNATA 721_ KGQKA 726_ ANLDL 731_ KKKMK 736_ MQALE 741_ NKMRN 746_ KKMAA 751_ARAAA
1: Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system (By similarity). The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15 (By similarity). MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located (By similarity). TMC1 MET channel is highly permeable to calcium and likely transports monovalent cations (By similarity). Also involved in vestibular hair cells transduction current (By similarity)