Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)
1_MEPQR 6_ RELLA 11_ QCQQS 16_ LAQAM 21_ TEVEA 26_ VLGLL 31_ EAAGA 36_ LSPGE 41_ RRQLD 46_ EEAGG 51_ AKAEL 56_ LLKLL 61_ LAKER 66_ DHFQD 71_ LRAAL 76_ EKTQP 81_ HLLPI 86_ LYLNG 91_ VVGPP 96_ QPAEG 101_ AGSTY 106_ SVLST 111_ MPSDS 116_ ESSSS 121_ LSSVG 126_ TTGKA 131_ PSPPP 136_ LLTDQ 141_ QVNEK 146_ VENLS 151_ IQLRL 156_ MTRER 161_ NELRK 166_ RLAFA 171_ THGTA 176_ FDKRP 181_ YHRLN 186_ PDYER 191_ LKIQC 196_ VRAMS 201_ DLQSL 206_ QNQHT 211_ NALKR 216_ CEEVA 221_ KETDF 226_ YHTLH 231_ SRLLS 236_ DQTRL 241_ KDDVD 246_ MLRRE 251_ NGQLL 256_ RERNL 261_ LQQSW 266_ EDMKR 271_ LHEED 276_ QKEIG 281_ DLRAQ 286_ QQQVL 291_ KHNGS 296_ SEILN 301_ KLYDT 306_ AMDKL 311_ EVVKK 316_ DYDAL 321_ RKRYS 326_ EKVAI 331_ HNADL 336_ SRLEQ 341_ LGEEN 346_ QRLLK 351_ QTEML 356_ TQQRD 361_ TAIQL 366_ QHQCA 371_ LSLRR 376_ FEAIH 381_ HELNK 386_ ATAQN 391_ KDLQW 396_ EMELL 401_ QSELT 406_ ELRTT 411_ QVKTA 416_ KESEK 421_ YREER 426_ DAVYS 431_ EYKLI 436_ MSERD 441_ QVISE 446_ LDKLQ 451_ TEVEL 456_ AESKL 461_ KSSTS 466_ EKKAA 471_ NEEME 476_ ALRQI 481_ KDTVT 486_ MDAGR 491_ ANKEV 496_ EILRK 501_ QCKAL 506_ CQELK 511_ EALQE 516_ ADVAK 521_ CRRDW 526_ AFQER 531_ DKIVA 536_ ERDSI 541_ RTLCD 546_ NLRRE 551_ RDRAV 556_ SELAE 561_ ALRSL 566_ DDTRK 571_ QKNDV 576_ SRELK 581_ ELKEQ 586_ MESQL 591_ EKEAR 596_ FRQLM 601_ AHSSH 606_ DSAID 611_ TDSME 616_ WETEV 621_ VEFER 626_ ETEDI 631_ DLKAL 636_ GFDMA 641_ EGVNE 646_ PCFPG 651_ DCGIF 656_ VTKVD 661_ KGSIA 666_ DGRLR 671_ VNDWL 676_ LRIND 681_ VDLIN 686_ KDKKQ 691_ AIKAL 696_ LNGEG 701_ AINMV 706_ VRRRK 711_ SLGGK 716_ VVTPL 721_ HINLS 726_ GQKDS 731_ GISLE 736_ NGVYA 741_ AAVLP 746_ GSPAA 751_ KEGSL 756_ AVGDR 761_ IVAIN 766_ GIALD 771_ NKSLN 776_ ECESL 781_ LRSCQ 786_ DSLTL 791_ SLLKV 796_ FPQSS 801_ SWSGQ 806_ NIFEN 811_ IKDSD 816_ KMLSF 821_ RAHGP 826_ EVQAH 831_ NKRNL 836_ IQHNN 841_ STQTD 846_ IFYTD 851_ RLEDR 856_ KEPGP 861_ PGGSS 866_ SFLHK 871_ PFPGG 876_ PLQVC 881_ PQACP 886_ SASER 891_ SLSSF 896_ RSDAS 901_ GDRGF 906_ GLVDV 911_ RGRRP 916_ LLPFE 921_ TEVGP 926_ CGVGE 931_ ASLDK 936_ ADSEG 941_ SNSGG 946_ TWPKA 951_ MLSST 956_ AVPEK 961_ LSVYK 966_ KPKQR 971_ KSIFD 976_ PNTFK 981_ RPQTP 986_ PKIDY 991_ LLPGP 996_ GPAHS 1001_ PQPSK 1006_ RAGPL 1011_ TPPKP 1016_ PRRSD 1021_ SIKFQ 1026_ HRLET 1031_ SSESE 1036_ ATLVG 1041_ SSPST 1046_ SPPSA 1051_ LPPDV 1056_ DPGEP 1061_ MHASP 1066_ PRKAR 1071_ VRIAS 1076_ SYYPE 1081_ GDGDS 1086_ SHLPA 1091_ KKSCD 1096_ EDLTS 1101_ QKVDE 1106_ LGQKR 1111_ RRPKS 1116_ APSFR 1121_ PKLAP 1126_ VVIPA 1131_ QFLEE 1136_ QKCVP 1141_ ASGEL 1146_ SPELQ 1151_ EWAPY 1156_ SPGHS 1161_ SRHSN 1166_ PPLYP 1171_ SRPSV 1176_ GTVPR 1181_ SLTPS 1186_ TTVSS 1191_ ILRNP 1196_ IYTVR 1201_ SHRVG 1206_ PCSSP 1211_ PAARD 1216_ AGPQG 1221_ LHPSV 1226_ QHQGR 1231_ LSLDL 1236_ SHRTC 1241_ SDYSE 1246_ MRATH 1251_ GSNSL 1256_ PSSAR 1261_ LGSSS 1266_ NLQFK 1271_ AERIK 1276_ IPSTP 1281_ RYPRS 1286_ VVGSE 1291_ RGSVS 1296_ HSECS 1301_ TPPQS 1306_ PLNID 1311_ TLSSC 1316_ SQSQT 1321_ SASTL 1326_ PRIAV 1331_ NPASL 1336_ GERRK 1341_ DRPYV 1346_ EEPRH 1351_ VKVQK 1356_ GSEPL 1361_ GISIV 1366_ SGEKG 1371_ GIYVS 1376_ KVTVG 1381_ SIAHQ 1386_ AGLEY 1391_ GDQLL 1396_ EFNGI 1401_ NLRSA 1406_ TEQQA 1411_ RLIIG 1416_ QQCDT 1421_ ITILA 1426_ QYNPH 1431_ VHQLS 1436_ SHSRS 1441_ SSHLD 1446_ PAGTH 1451_ STLQG 1456_ SGTTT 1461_ PEHPS 1466_ VIDPL 1471_ MEQDE 1476_ GPSTP 1481_ PAKQS 1486_ SSRIA 1491_ GDANK 1496_ KTLEP 1501_ RVVFI 1506_ KKSQL 1511_ ELGVH 1516_ LCGGN 1521_ LHGVF 1526_ VAEVE 1531_ DDSPA 1536_ KGPDG 1541_ LVPGD 1546_ LILEY 1551_ GSLDV 1556_ RNKTV 1561_ EEVYV 1566_ EMLKP 1571_ RDGVR 1576_ LKVQY 1581_ RPEEF 1586_ TKAKG 1591_ LPGDS 1596_ FYIRA 1601_ LYDRL 1606_ ADVEQ 1611_ ELSFK 1616_ KDDIL 1621_ YVDDT 1626_ LPQGT 1631_ FGSWM 1636_ AWQLD 1641_ ENAQK 1646_ IQRGQ 1651_ IPSKY 1656_ VMDQE 1661_ FSRRL 1666_ SMSEV 1671_ KDDNS 1676_ ATKTL 1681_ SAAAR 1686_ RSFFR 1691_ RKHKH 1696_ KRSGS 1701_ KDGKD 1706_ LLALD 1711_ AFSSD 1716_ SIPLF 1721_ EDSVS 1726_ LAYQR 1731_ VQKVD 1736_ CTALR 1741_ PVLIL 1746_ GPLLD 1751_ VVKEM 1756_ LVNEA 1761_ PGKFC 1766_ RCPLE 1771_ VMKAS 1776_ QQAIE 1781_ RGVKD 1786_ CLFVD 1791_ YKRRS 1796_ GHFDV 1801_ TTVAS 1806_ IKEIT 1811_ EKNRH 1816_ CLLDI 1821_ APHAI 1826_ ERLHH 1831_ MHIYP 1836_ IVIFI 1841_ HYKSA 1846_ KHIKE 1851_ QRDPI 1856_ YLRDK 1861_ VTQRH 1866_ SKEQF 1871_ EAAQK 1876_ LEQEY 1881_ SRYFT 1886_ GVIQG 1891_ GALSS 1896_ ICTQI 1901_ LAMVN 1906_ QEQNK 1911_VLWIP
1: Acts as a regulator of the Hippo signaling pathway (PubMed:28087714, PubMed:28169360). Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1 (PubMed:28087714). Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion (PubMed:28169360). Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons; regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity)