Alkaline ceramidase 1 (AlkCDase 1) (Alkaline CDase 1) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 3) (N-acylsphingosine amidohydrolase 3)
1_MPSIF 6_ AYQSS 11_ EVDWC 16_ ESNFQ 21_ YSELV 26_ AEFYN 31_ TFSNI 36_ PFFIF 41_ GPLMM 46_ LLMHP 51_ YAQKR 56_ SRYIY 61_ VVWVL 66_ FMIIG 71_ LFSMY 76_ FHMTL 81_ SFLGQ 86_ LLDEI 91_ AILWL 96_ LGSGY 101_ SIWMP 106_ RCYFP 111_ SFLGG 116_ NRSQF 121_ IRLVF 126_ ITTVV 131_ STLLS 136_ FLRPT 141_ VNAYA 146_ LNSIA 151_ LHILY 156_ IVCQE 161_ YRKTS 166_ NKELR 171_ HLIEV 176_ SVVLW 181_ AVALT 186_ SWISD 191_ RLLCS 196_ FWQRI 201_ HFFYL 206_ HSIWH 211_ VLISI 216_ TFPYG 221_ MVTMA 226_ LVDAN 231_ YEMPG 236_ ETLKV 241_ RYWPR 246_ DSWPV 251_ GLPYV 256_EIRGD
1: Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:17713573, PubMed:20207939, PubMed:20628055). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875). Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:17713573, PubMed:20207939). May also hydrolyze dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:17713573)