CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f)
1_MPLLT 6_ LYLLL 11_ FWLSG 16_ YSIVT 21_ QITGP 26_ TTVNG 31_ LERGS 36_ LTVQC 41_ VYRSG 46_ WETYL 51_ KWWCR 56_ GAIWR 61_ DCKIL 66_ VKTSG 71_ SEQEV 76_ KRDRV 81_ SIKDN 86_ QKNRT 91_ FTVTM 96_ EDLMK 101_ TDADT 106_ YWCGI 111_ EKTGN 116_ DLGVT 121_ VQVTI 126_ DPAPV 131_ TQEET 136_ SSSPT 141_ LTGHH 146_ LDNRH 151_ KLLKL 156_ SVLLP 161_ LIFTI 166_ LLLLL 171_ VAASL 176_ LAWRM 181_ MKYQQ 186_ KAAGM 191_ SPEQV 196_ LQPLE 201_ GDLCY 206_ ADLTL 211_ QLAGT 216_ SPQKA 221_ TTKLS 226_ SAQVD 231_ QVEVE 236_ YVTMA 241_ SLPKE 246_ DISYA 251_ SLTLG 256_ AEDQE 261_ PTYCN 266_ MGHLS 271_ SHLPG 276_ RGPEE 281_PTEYS
1: Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition; recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity)