Glucosamine-6-phosphate isomerase 2 (EC 3.5.99.6) (Glucosamine-6-phosphate deaminase 2) (GNPDA 2) (GlcN6P deaminase 2) (Glucosamine-6-phosphate isomerase SB52)
1_MRLVI 6_ LDNYD 11_ LASEW 16_ AAKYI 21_ CNRII 26_ QFKPG 31_ QDRYF 36_ TLGLP 41_ TGSTP 46_ LGCYK 51_ KLIEY 56_ HKNGH 61_ LSFKY 66_ VKTFN 71_ MDEYV 76_ GLPRN 81_ HPESY 86_ HSYMW 91_ NNFFK 96_ HIDID 101_ PNNAH 106_ ILDGN 111_ AADLQ 116_ AECDA 121_ FENKI 126_ KEAGG 131_ IDLFV 136_ GGIGP 141_ DGHIA 146_ FNEPG 151_ SSLVS 156_ RTRLK 161_ TLAMD 166_ TILAN 171_ AKYFD 176_ GDLSK 181_ VPTMA 186_ LTVGV 191_ GTVMD 196_ AREVM 201_ ILITG 206_ AHKAF 211_ ALYKA 216_ IEEGV 221_ NHMWT 226_ VSAFQ 231_ QHPRT 236_ IFVCD 241_ EDATL 246_ ELRVK 251_ TVKYF 256_ KGLMH 261_ VHNKL 266_ VDPLF 271_SMKDG
1: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling