Hydroxycarboxylic acid receptor 2 (G-protein coupled receptor 109A) (G-protein coupled receptor HM74A) (Niacin receptor 1) (Nicotinic acid receptor)
1_MNRHH 6_ LQDHF 11_ LEIDK 16_ KNCCV 21_ FRDDF 26_ IVKVL 31_ PPVLG 36_ LEFIF 41_ GLLGN 46_ GLALW 51_ IFCFH 56_ LKSWK 61_ SSRIF 66_ LFNLA 71_ VADFL 76_ LIICL 81_ PFLMD 86_ NYVRR 91_ WDWKF 96_ GDIPC 101_ RLMLF 106_ MLAMN 111_ RQGSI 116_ IFLTV 121_ VAVDR 126_ YFRVV 131_ HPHHA 136_ LNKIS 141_ NRTAA 146_ IISCL 151_ LWGIT 156_ IGLTV 161_ HLLKK 166_ KMPIQ 171_ NGGAN 176_ LCSSF 181_ SICHT 186_ FQWHE 191_ AMFLL 196_ EFFLP 201_ LGIIL 206_ FCSAR 211_ IIWSL 216_ RQRQM 221_ DRHAK 226_ IKRAI 231_ TFIMV 236_ VAIVF 241_ VICFL 246_ PSVVV 251_ RIRIF 256_ WLLHT 261_ SGTQN 266_ CEVYR 271_ SVDLA 276_ FFITL 281_ SFTYM 286_ NSMLD 291_ PVVYY 296_ FSSPS 301_ FPNFF 306_ STLIN 311_ RCLQR 316_ KMTGE 321_ PDNNR 326_ STSVE 331_ LTGDP 336_ NKTRG 341_ APEAL 346_ MANSG 351_ EPWSP 356_SYLGP
1: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide