Volume-regulated anion channel subunit LRRC8C (Factor for adipocyte differentiation 158) (Leucine-rich repeat-containing protein 8C)
1_MIPVT 6_ EFRQF 11_ SEQQP 16_ AFRVL 21_ KPWWD 26_ VFTDY 31_ LSVAM 36_ LMIGV 41_ FGCTL 46_ QVMQD 51_ KIICL 56_ PKRVQ 61_ PAQNH 66_ SSLSN 71_ VSQAV 76_ ASTTP 81_ LPPPK 86_ PSPAN 91_ PITVE 96_ MKGLK 101_ TDLDL 106_ QQYSF 111_ INQMC 116_ YERAL 121_ HWYAK 126_ YFPYL 131_ VLIHT 136_ LVFML 141_ CSNFW 146_ FKFPG 151_ SSSKI 156_ EHFIS 161_ ILGKC 166_ FDSPW 171_ TTRAL 176_ SEVSG 181_ EDSEE 186_ KDNRK 191_ NNMNR 196_ SNTIQ 201_ SGPED 206_ SLVNS 211_ QSLKS 216_ IPEKF 221_ VVDKS 226_ TAGAL 231_ DKKEG 236_ EQAKA 241_ LFEKV 246_ KKFRL 251_ HVEEG 256_ DILYA 261_ MYVRQ 266_ TVLKV 271_ IKFLI 276_ IIAYN 281_ SALVS 286_ KVQFT 291_ VDCNV 296_ DIQDM 301_ TGYKN 306_ FSCNH 311_ TMAHL 316_ FSKLS 321_ FCYLC 326_ FVSIY 331_ GLTCL 336_ YTLYW 341_ LFYRS 346_ LREYS 351_ FEYVR 356_ QETGI 361_ DDIPD 366_ VKNDF 371_ AFMLH 376_ MIDQY 381_ DPLYS 386_ KRFAV 391_ FLSEV 396_ SENKL 401_ KQLNL 406_ NNEWT 411_ PDKLR 416_ QKLQT 421_ NAHNR 426_ LELPL 431_ IMLSG 436_ LPDTV 441_ FEITE 446_ LQSLK 451_ LEIIK 456_ NVMIP 461_ ATIAQ 466_ LDNLQ 471_ ELSLH 476_ QCSVK 481_ IHSAA 486_ LSFLK 491_ ENLKV 496_ LSVKF 501_ DDMRE 506_ LPPWM 511_ YGLRN 516_ LEELY 521_ LVGSL 526_ SHDIS 531_ RNVTL 536_ ESLRD 541_ LKSLK 546_ ILSIK 551_ SNVSK 556_ IPQAV 561_ VDVSS 566_ HLQKM 571_ CIHND 576_ GTKLV 581_ MLNNL 586_ KKMTN 591_ LTELE 596_ LVHCD 601_ LERIP 606_ HAVFS 611_ LLSLQ 616_ ELDLK 621_ ENNLK 626_ SIEEI 631_ VSFQH 636_ LRKLT 641_ VLKLW 646_ HNSIT 651_ YIPEH 656_ IKKLT 661_ SLERL 666_ SFSHN 671_ KIEVL 676_ PSHLF 681_ LCNKI 686_ RYLDL 691_ SYNDI 696_ RFIPP 701_ EIGVL 706_ QSLQY 711_ FSITC 716_ NKVES 721_ LPDEL 726_ YFCKK 731_ LKTLK 736_ IGKNS 741_ LSVLS 746_ PKIGN 751_ LLFLS 756_ YLDVK 761_ GNHFE 766_ ILPPE 771_ LGDCR 776_ ALKRA 781_ GLVVE 786_ DALFE 791_ TLPSD 796_VREQM
1: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731, PubMed:36897307, PubMed:39623139). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731)