Gene name: ACMSD

Uniprot entry:

Q8TDX5

Protein names:

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (EC 4.1.1.45) (Picolinate carboxylase)

Protein sequence:

1_MKIDI 6_ HSHIL 11_ PKEWP 16_ DLKKR 21_ FGYGG 26_ WVQLQ 31_ HHSKG 36_ EAKLL 41_ KDGKV 46_ FRVVR 51_ ENCWD 56_ PEVRI 61_ REMDQ 66_ KGVTV 71_ QALST 76_ VPVMF 81_ SYWAK 86_ PEDTL 91_ NLCQL 96_ LNNDL 101_ ASTVV 106_ SYPRR 111_ FVGLG 116_ TLPMQ 121_ APELA 126_ VKEME 131_ RCVKE 136_ LGFPG 141_ VQIGT 146_ HVNEW 151_ DLNAQ 156_ ELFPV 161_ YAAAE 166_ RLKCS 171_ LFVHP 176_ WDMQM 181_ DGRMA 186_ KYWLP 191_ WLVGM 196_ PAETT 201_ IAICS 206_ MIMGG 211_ VFEKF 216_ PKLKV 221_ CFAHG 226_ GGAFP 231_ FTVGR 236_ ISHGF 241_ SMRPD 246_ LCAQD 251_ NPMNP 256_ KKYLG 261_ SFYTD 266_ ALVHD 271_ PLSLK 276_ LLTDV 281_ IGKDK 286_ VILGT 291_ DYPFP 296_ LGELE 301_ PGKLI 306_ ESMEE 311_ FDEET 316_ KNKLK 321_ AGNAL 326_ AFLGL 331_ERKQF

Protein annotations

Protein functions:

1: Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway