Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CsGalNAcT-1) (EC 2.4.1.174) (Chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1) (Beta4GalNAcT-1)
1_MMMVR 6_ RGLLA 11_ WISRV 16_ VVLLV 21_ LLCCA 26_ ISVLY 31_ MLACT 36_ PKGDE 41_ EQLAL 46_ PRANS 51_ PTGKE 56_ GYQAV 61_ LQEWE 66_ EQHRN 71_ YVSSL 76_ KRQIA 81_ QLKEE 86_ LQERS 91_ EQLRN 96_ GQYQA 101_ SDAAG 106_ LGLDR 111_ SPPEK 116_ TQADL 121_ LAFLH 126_ SQVDK 131_ AEVNA 136_ GVKLA 141_ TEYAA 146_ VPFDS 151_ FTLQK 156_ VYQLE 161_ TGLTR 166_ HPEEK 171_ PVRKD 176_ KRDEL 181_ VEAIE 186_ SALET 191_ LNSPA 196_ ENSPN 201_ HRPYT 206_ ASDFI 211_ EGIYR 216_ TERDK 221_ GTLYE 226_ LTFKG 231_ DHKHE 236_ FKRLI 241_ LFRPF 246_ GPIMK 251_ VKNEK 256_ LNMAN 261_ TLINV 266_ IVPLA 271_ KRVDK 276_ FRQFM 281_ QNFRE 286_ MCIEQ 291_ DGRVH 296_ LTVVY 301_ FGKEE 306_ INEVK 311_ GILEN 316_ TSKAA 321_ NFRNF 326_ TFIQL 331_ NGEFS 336_ RGKGL 341_ DVGAR 346_ FWKGS 351_ NVLLF 356_ FCDVD 361_ IYFTS 366_ EFLNT 371_ CRLNT 376_ QPGKK 381_ VFYPV 386_ LFSQY 391_ NPGII 396_ YGHHD 401_ AVPPL 406_ EQQLV 411_ IKKET 416_ GFWRD 421_ FGFGM 426_ TCQYR 431_ SDFIN 436_ IGGFD 441_ LDIKG 446_ WGGED 451_ VHLYR 456_ KYLHS 461_ NLIVV 466_ RTPVR 471_ GLFHL 476_ WHEKR 481_ CMDEL 486_ TPEQY 491_ KMCMQ 496_ SKAMN 501_ EASHG 506_ QLGML 511_ VFRHE 516_ IEAHL 521_ RKQKQ 526_KTSSK
1: Transfers 1,4-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of glucuronic acid (GlcUA). Required for addition of the first GalNAc to the core tetrasaccharide linker and for elongation of chondroitin chains. Important role in chondroitin chain biosynthesis in cartilage formation and subsequent endochondral ossification (PubMed:11788602, PubMed:12163485, PubMed:12446672, PubMed:17145758, PubMed:31705726). Moreover, is involved in the metabolism of aggrecan (By similarity)