Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)
1_MDEQS 6_ QGMQG 11_ PPVPQ 16_ FQPQK 21_ ALRPD 26_ MGYNT 31_ LANFR 36_ IEKKI 41_ GRGQF 46_ SEVYR 51_ AACLL 56_ DGVPV 61_ ALKKV 66_ QIFDL 71_ MDAKA 76_ RADCI 81_ KEIDL 86_ LKQLN 91_ HPNVI 96_ KYYAS 101_ FIEDN 106_ ELNIV 111_ LELAD 116_ AGDLS 121_ RMIKH 126_ FKKQK 131_ RLIPE 136_ RTVWK 141_ YFVQL 146_ CSALE 151_ HMHSR 156_ RVMHR 161_ DIKPA 166_ NVFIT 171_ ATGVV 176_ KLGDL 181_ GLGRF 186_ FSSKT 191_ TAAHS 196_ LVGTP 201_ YYMSP 206_ ERIHE 211_ NGYNF 216_ KSDIW 221_ SLGCL 226_ LYEMA 231_ ALQSP 236_ FYGDK 241_ MNLYS 246_ LCKKI 251_ EQCDY 256_ PPLPS 261_ DHYSE 266_ ELRQL 271_ VNMCI 276_ NPDPE 281_ KRPDV 286_ TYVYD 291_ VAKRM 296_HACTA
1: Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:17101132, PubMed:19941817, PubMed:31409757). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:17586473, PubMed:19414596, PubMed:19941817, PubMed:26522158, PubMed:31409757). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (PubMed:31409757). Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (PubMed:26642356, PubMed:36442502, PubMed:39173637). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (PubMed:26642356, PubMed:31189953, PubMed:36442502, PubMed:39173637). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (PubMed:26642356, PubMed:31189953)