[F-actin]-monooxygenase MICAL1 (EC 1.14.13.225) (EC 1.6.3.1) (Molecule interacting with CasL protein 1) (MICAL-1) (NEDD9-interacting protein with calponin homology and LIM domains)
1_MASPT 6_ STNPA 11_ HAHFE 16_ SFLQA 21_ QLCQD 26_ VLSSF 31_ QELCG 36_ ALGLE 41_ PGGGL 46_ PQYHK 51_ IKDQL 56_ NYWSA 61_ KSLWT 66_ KLDKR 71_ AGQPV 76_ YQQGR 81_ ACTST 86_ KCLVV 91_ GAGPC 96_ GLRVA 101_ VELAL 106_ LGARV 111_ VLVEK 116_ RTKFS 121_ RHNVL 126_ HLWPF 131_ TIHDL 136_ RALGA 141_ KKFYG 146_ RFCTG 151_ TLDHI 156_ SIRQL 161_ QLLLL 166_ KVALL 171_ LGVEI 176_ HWGVT 181_ FTGLQ 186_ PPPRK 191_ GSGWR 196_ AQLQP 201_ NPPAQ 206_ LANYE 211_ FDVLI 216_ SAAGG 221_ KFVPE 226_ GFKVR 231_ EMRGK 236_ LAIGI 241_ TANFV 246_ NGRTV 251_ EETQV 256_ PEISG 261_ VARIY 266_ NQSFF 271_ QSLLK 276_ ATGID 281_ LENIV 286_ YYKDD 291_ THYFV 296_ MTAKK 301_ QCLLR 306_ LGVLR 311_ QDWPD 316_ TNRLL 321_ GSANV 326_ VPEAL 331_ QRFTR 336_ AAADF 341_ ATHGK 346_ LGKLE 351_ FAQDA 356_ HGQPD 361_ VSAFD 366_ FTSMM 371_ RAESS 376_ ARVQE 381_ KHGAR 386_ LLLGL 391_ VGDCL 396_ VEPFW 401_ PLGTG 406_ VARGF 411_ LAAFD 416_ AAWMV 421_ KRWAE 426_ GAESL 431_ EVLAE 436_ RESLY 441_ QLLSQ 446_ TSPEN 451_ MHRNV 456_ AQYGL 461_ DPATR 466_ YPNLN 471_ LRAVT 476_ PNQVR 481_ DLYDV 486_ LAKEP 491_ VQRNN 496_ DKTDT 501_ GMPAT 506_ GSAGT 511_ QEELL 516_ RWCQE 521_ QTAGY 526_ PGVHV 531_ SDLSS 536_ SWADG 541_ LALCA 546_ LVYRL 551_ QPGLL 556_ EPSEL 561_ QGLGA 566_ LEATA 571_ WALKV 576_ AENEL 581_ GITPV 586_ VSAQA 591_ VVAGS 596_ DPLGL 601_ IAYLS 606_ HFHSA 611_ FKSMA 616_ HSPGP 621_ VSQAS 626_ PGTSS 631_ AVLFL 636_ SKLQR 641_ TLQRS 646_ RAKEN 651_ AEDAG 656_ GKKLR 661_ LEMEA 666_ ETPST 671_ EVPPD 676_ PEPGV 681_ PLTPP 686_ SQHQE 691_ AGAGD 696_ LCALC 701_ GEHLY 706_ VLERL 711_ CVNGH 716_ FFHRS 721_ CFRCH 726_ TCEAT 731_ LWPGG 736_ YEQHP 741_ GDGHF 746_ YCLQH 751_ LPQTD 756_ HKAEG 761_ SDRGP 766_ ESPEL 771_ PTPSE 776_ NSMPP 781_ GLSTP 786_ TASQE 791_ GAGPV 796_ PDPSQ 801_ PTRRQ 806_ IRLSS 811_ PERQR 816_ LSSLN 821_ LTPDP 826_ EMEPP 831_ PKPPR 836_ SCSAL 841_ ARHAL 846_ ESSFV 851_ GWGLP 856_ VQSPQ 861_ ALVAM 866_ EKEEK 871_ ESPFS 876_ SEEEE 881_ EDVPL 886_ DSDVE 891_ QALQT 896_ FAKTS 901_ GTMNN 906_ YPTWR 911_ RTLLR 916_ RAKEE 921_ EMKRF 926_ CKAQT 931_ IQRRL 936_ NEIEA 941_ ALREL 946_ EAEGV 951_ KLELA 956_ LRRQS 961_ SSPEQ 966_ QKKLW 971_ VGQLL 976_ QLVDK 981_ KNSLV 986_ AEEAE 991_ LMITV 996_ QELNL 1001_ EEKQW 1006_ QLDQE 1011_ LRGYM 1016_ NREEN 1021_ LKTAA 1026_ DRQAE 1031_ DQVLR 1036_ KLVDL 1041_ VNQRD 1046_ ALIRF 1051_ QEERR 1056_ LSELA 1061_LGTGA
1: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:29343822). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (PubMed:21864500, PubMed:26845023, PubMed:29343822). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking. Promotes endosomal tubule extension by associating with RAB8 (RAB8A or RAB8B), RAB10 and GRAF (GRAF1/ARHGAP26 or GRAF2/ARHGAP10) on the endosomal membrane which may connect GRAFs to Rabs, thereby participating in neosynthesized Rab8-Rab10-Rab11-dependent protein export (PubMed:32344433)