A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAM-TS 15) (ADAM-TS15) (ADAMTS-15) (EC 3.4.24.-)
1_MLLLG 6_ ILTLA 11_ FAGRT 16_ AGGSE 21_ PEREV 26_ VVPIR 31_ LDPDI 36_ NGRRY 41_ YWRGP 46_ EDSGD 51_ QGLIF 56_ QITAF 61_ QEDFY 66_ LHLTP 71_ DAQFL 76_ APAFS 81_ TEHLG 86_ VPLQG 91_ LTGGS 96_ SDLRR 101_ CFYSG 106_ DVNAE 111_ PDSFA 116_ AVSLC 121_ GGLRG 126_ AFGYR 131_ GAEYV 136_ ISPLP 141_ NASAP 146_ AAQRN 151_ SQGAH 156_ LLQRR 161_ GVPGG 166_ PSGDP 171_ TSRCG 176_ VASGW 181_ NPAIL 186_ RALDP 191_ YKPRR 196_ AGFGE 201_ SRSRR 206_ RSGRA 211_ KRFVS 216_ IPRYV 221_ ETLVV 226_ ADESM 231_ VKFHG 236_ ADLEH 241_ YLLTL 246_ LATAA 251_ RLYRH 256_ PSILN 261_ PINIV 266_ VVKVL 271_ LLRDR 276_ DSGPK 281_ VTGNA 286_ ALTLR 291_ NFCAW 296_ QKKLN 301_ KVSDK 306_ HPEYW 311_ DTAIL 316_ FTRQD 321_ LCGAT 326_ TCDTL 331_ GMADV 336_ GTMCD 341_ PKRSC 346_ SVIED 351_ DGLPS 356_ AFTTA 361_ HELGH 366_ VFNMP 371_ HDNVK 376_ VCEEV 381_ FGKLR 386_ ANHMM 391_ SPTLI 396_ QIDRA 401_ NPWSA 406_ CSAAI 411_ ITDFL 416_ DSGHG 421_ DCLLD 426_ QPSKP 431_ ISLPE 436_ DLPGA 441_ SYTLS 446_ QQCEL 451_ AFGVG 456_ SKPCP 461_ YMQYC 466_ TKLWC 471_ TGKAK 476_ GQMVC 481_ QTRHF 486_ PWADG 491_ TSCGE 496_ GKLCL 501_ KGACV 506_ ERHNL 511_ NKHRV 516_ DGSWA 521_ KWDPY 526_ GPCSR 531_ TCGGG 536_ VQLAR 541_ RQCTN 546_ PTPAN 551_ GGKYC 556_ EGVRV 561_ KYRSC 566_ NLEPC 571_ PSSAS 576_ GKSFR 581_ EEQCE 586_ AFNGY 591_ NHSTN 596_ RLTLA 601_ VAWVP 606_ KYSGV 611_ SPRDK 616_ CKLIC 621_ RANGT 626_ GYFYV 631_ LAPKV 636_ VDGTL 641_ CSPDS 646_ TSVCV 651_ QGKCI 656_ KAGCD 661_ GNLGS 666_ KKRFD 671_ KCGVC 676_ GGDNK 681_ SCKKV 686_ TGLFT 691_ KPMHG 696_ YNFVV 701_ AIPAG 706_ ASSID 711_ IRQRG 716_ YKGLI 721_ GDDNY 726_ LALKN 731_ SQGKY 736_ LLNGH 741_ FVVSA 746_ VERDL 751_ VVKGS 756_ LLRYS 761_ GTGTA 766_ VESLQ 771_ ASRPI 776_ LEPLT 781_ VEVLS 786_ VGKMT 791_ PPRVR 796_ YSFYL 801_ PKEPR 806_ EDKSS 811_ HPKDP 816_ RGPSV 821_ LHNSV 826_ LSLSN 831_ QVEQP 836_ DDRPP 841_ ARWVA 846_ GSWGP 851_ CSASC 856_ GSGLQ 861_ KRAVD 866_ CRGSA 871_ GQRTV 876_ PACDA 881_ AHRPV 886_ ETQAC 891_ GEPCP 896_ TWELS 901_ AWSPC 906_ SKSCG 911_ RGFQR 916_ RSLKC 921_ VGHGG 926_ RLLAR 931_ DQCNL 936_ HRKPQ 941_ELDFC
1: Metalloprotease which has proteolytic activity against the proteoglycan VCAN, cleaving it at the 'Glu-1428-|-1429-Ala' site. Cleaves VCAN in the pericellular matrix surrounding myoblasts, facilitating myoblast contact and fusion which is required for skeletal muscle development and regeneration