Grainyhead-like protein 3 homolog (Sister of mammalian grainyhead) (Transcription factor CP2-like 4)
1_MSNEL 6_ DFRSV 11_ RLLKN 16_ DPVNL 21_ QKFSY 26_ TSEDE 31_ AWKTY 36_ LENPL 41_ TAATK 46_ AMMRV 51_ NGDDD 56_ SVAAL 61_ SFLYD 66_ YYMGP 71_ KEKRI 76_ LSSST 81_ GGRND 86_ QGKRY 91_ YHGME 96_ YETDL 101_ TPLES 106_ PTHLM 111_ KFLTE 116_ NVSGT 121_ PEYPD 126_ LLKKN 131_ NLMSL 136_ EGALP 141_ TPGKA 146_ APLPA 151_ GPSKL 156_ EAGSV 161_ DSYLL 166_ PTTDM 171_ YDNGS 176_ LNSLF 181_ ESIHG 186_ VPPTQ 191_ RWQPD 196_ STFKD 201_ DPQES 206_ MLFPD 211_ ILKTS 216_ PEPPC 221_ PEDYP 226_ SLKSD 231_ FEYTL 236_ GSPKA 241_ IHIKS 246_ GESPM 251_ AYLNK 256_ GQFYP 261_ VTLRT 266_ PAGGK 271_ GLALS 276_ SNKVK 281_ SVVMV 286_ VFDNE 291_ KVPVE 296_ QLRFW 301_ KHWHS 306_ RQPTA 311_ KQRVI 316_ DVADC 321_ KENFN 326_ TVEHI 331_ EEVAY 336_ NALSF 341_ VWNVN 346_ EEAKV 351_ FIGVN 356_ CLSTD 361_ FSSQK 366_ GVKGV 371_ PLNLQ 376_ IDTYD 381_ CGLGT 386_ ERLVH 391_ RAVCQ 396_ IKIFC 401_ DKGAE 406_ RKMRD 411_ DERKQ 416_ FRRKV 421_ KCPDS 426_ SNSGV 431_ KGCLL 436_ SGFRG 441_ NETTY 446_ LRPET 451_ DLETP 456_ PVLFI 461_ PNVHF 466_ SSLQR 471_ SGGAA 476_ PSAGP 481_ SSSNR 486_ LPLKR 491_ TCSPF 496_ TEEFE 501_ PLPSK 506_ QAKEG 511_ DLQRV 516_ LLYVR 521_ RETEE 526_ VFDAL 531_ MLKTP 536_ DLKGL 541_ RNAIS 546_ EKYGF 551_ PEENI 556_ YKVYK 561_ KCKRG 566_ ETSLL 571_ HPRLS 576_ RHPPP 581_ DCLEC 586_ SHPVT 591_ QVRNM 596_ GFGDG 601_ FWRQR 606_ DLDSN 611_ PSPTT 616_ VNSLH 621_FTVNS
1: Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair but is essential to form the epidermal barrier with TGM3 as critical direct target gene among others. Despite being dispensable during normal epidermal homeostasis in the adulthood, is again required for barrier repair after immune-mediated epidermal damage, regulates distinct gene batteries in embryonic epidermal differentiation and adult epidermal barrier reformation after injury. Plays unique and cooperative roles with GRHL2 in establishing distinct zones of primary neurulation. Essential for spinal closure, functions cooperatively with GRHL2 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure (By similarity). Also required for proper development of the oral periderm (PubMed:24360809). No genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity (PubMed:21081122)