2-phosphoxylose phosphatase 1 (EC 3.1.3.-) (Acid phosphatase-like protein 2) (Xylosyl phosphatase) (epididymis luminal protein 124)
1_MLFRN 6_ RFLLL 11_ LALAA 16_ LLAFV 21_ SLSLQ 26_ FFHLI 31_ PVSTP 36_ KNGMS 41_ SKSRK 46_ RIMPD 51_ PVTEP 56_ PVTDP 61_ VYEAL 66_ LYCNI 71_ PSVAE 76_ RSMEG 81_ HAPHH 86_ FKLVS 91_ VHVFI 96_ RHGDR 101_ YPLYV 106_ IPKTK 111_ RPEID 116_ CTLVA 121_ NRKPY 126_ HPKLE 131_ AFISH 136_ MSKGS 141_ GASFE 146_ SPLNS 151_ LPLYP 156_ NHPLC 161_ EMGEL 166_ TQTGV 171_ VQHLQ 176_ NGQLL 181_ RDIYL 186_ KKHKL 191_ LPNDW 196_ SADQL 201_ YLETT 206_ GKSRT 211_ LQSGL 216_ ALLYG 221_ FLPDF 226_ DWKKI 231_ YFRHQ 236_ PSALF 241_ CSGSC 246_ YCPVR 251_ NQYLE 256_ KEQRR 261_ QYLLR 266_ LKNSQ 271_ LEKTY 276_ GEMAK 281_ IVDVP 286_ TKQLR 291_ AANPI 296_ DSMLC 301_ HFCHN 306_ VSFPC 311_ TRNGC 316_ VDMEH 321_ FKVIK 326_ THQIE 331_ DERER 336_ REKKL 341_ YFGYS 346_ LLGAH 351_ PILNQ 356_ TIGRM 361_ QRATE 366_ GRKEE 371_ LFALY 376_ SAHDV 381_ TLSPV 386_ LSALG 391_ LSEAR 396_ FPRFA 401_ ARLIF 406_ ELWQD 411_ REKPS 416_ EHSVR 421_ ILYNG 426_ VDVTF 431_ HTSFC 436_ QDHHK 441_ RSPKP 446_ MCPLE 451_ NLVRF 456_ VKRDM 461_ FVALG 466_ GSGTN 471_YYDAC
1: Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains