D-aminoacyl-tRNA deacylase 1 (DTD) (EC 3.1.1.96) (DNA-unwinding element-binding protein B) (DUE-B) (Gly-tRNA(Ala) deacylase) (Histidyl-tRNA synthase-related)
1_MKAVV 6_ QRVTR 11_ ASVTV 16_ GGEQI 21_ SAIGR 26_ GICVL 31_ LGISL 36_ EDTQK 41_ ELEHM 46_ VRKIL 51_ NLRVF 56_ EDESG 61_ KHWSK 66_ SVMDK 71_ QYEIL 76_ CVSQF 81_ TLQCV 86_ LKGNK 91_ PDFHL 96_ AMPTE 101_ QAEGF 106_ YNSFL 111_ EQLRK 116_ TYRPE 121_ LIKDG 126_ KFGAY 131_ MQVHI 136_ QNDGP 141_ VTIEL 146_ ESPAP 151_ GTATS 156_ DPKQL 161_ SKLEK 166_ QQQRK 171_ EKTRA 176_ KGPSE 181_ SSKER 186_ NTPRK 191_ EDRSA 196_ SSGAE 201_GDVSS
1: Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034)
2: An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality