Rhomboid-related protein 4 (RRP4) (EC 3.4.21.105) (Rhomboid domain-containing protein 1) (Rhomboid-like protein 4)
1_MQRRS 6_ RGINT 11_ GLILL 16_ LSQIF 21_ HVGIN 26_ NIPPV 31_ TLATL 36_ ALNIW 41_ FFLNP 46_ QKPLY 51_ SSCLS 56_ VEKCY 61_ QQKDW 66_ QRLLL 71_ SPLHH 76_ ADDWH 81_ LYFNM 86_ ASMLW 91_ KGINL 96_ ERRLG 101_ SRWFA 106_ YVITA 111_ FSVLT 116_ GVVYL 121_ LLQFA 126_ VAEFM 131_ DEPDF 136_ KRSCA 141_ VGFSG 146_ VLFAL 151_ KVLNN 156_ HYCPG 161_ GFVNI 166_ LGFPV 171_ PNRFA 176_ CWVEL 181_ VAIHL 186_ FSPGT 191_ SFAGH 196_ LAGIL 201_ VGLMY 206_ TQGPL 211_ KKIME 216_ ACAGG 221_ FSSSV 226_ GYPGR 231_ QYYFN 236_ SSGSS 241_ GYQDY 246_ YPHGR 251_ PDHYE 256_ EAPRN 261_ YDTYT 266_ AGLSE 271_ EEQLE 276_ RALQA 281_ SLWDR 286_ GNTRN 291_ SPPPY 296_ GFHLS 301_ PEEMR 306_RQRLH
1: Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia