E3 ubiquitin-protein ligase SH3RF2 (EC 2.3.2.27) (Heart protein phosphatase 1-binding protein) (HEPP1) (POSH-eliminating RING protein) (Protein phosphatase 1 regulatory subunit 39) (RING finger protein 158) (RING-type E3 ubiquitin transferase SH3RF2) (SH3 domain-containing RING finger protein 2)
1_MDDLT 6_ LLDLL 11_ ECPVC 16_ FEKLD 21_ VTAKV 26_ LPCQH 31_ TFCKP 36_ CLQRV 41_ FKAHK 46_ ELRCP 51_ ECRTP 56_ VFSNI 61_ EALPA 66_ NLLLV 71_ RLLDG 76_ VRSGQ 81_ SSGRG 86_ GSFRR 91_ PGTMT 96_ LQDGR 101_ KSRTN 106_ PRRLQ 111_ ASPFR 116_ LVPNV 121_ RIHMD 126_ GVPRA 131_ KALCN 136_ YRGQN 141_ PGDLR 146_ FNKGD 151_ IILLR 156_ RQLDE 161_ NWYQG 166_ EINGI 171_ SGNFP 176_ ASSVE 181_ VIKQL 186_ PQPPP 191_ LCRAL 196_ YNFDL 201_ RGKDK 206_ SENQD 211_ CLTFL 216_ KDDII 221_ TVISR 226_ VDENW 231_ AEGKL 236_ GDKVG 241_ IFPIL 246_ FVEPN 251_ LTARH 256_ LLEKN 261_ KGRQS 266_ SRTKN 271_ LSLVS 276_ SSSRG 281_ NTSTL 286_ RRGPG 291_ SRRKV 296_ PGQFS 301_ ITTAL 306_ NTLNR 311_ MVHSP 316_ SGRHM 321_ VEIST 326_ PVLIS 331_ SSNPS 336_ VITQP 341_ MEKAD 346_ VPSSC 351_ VGQVS 356_ TYHPA 361_ PVSPG 366_ HSTAV 371_ VSLPG 376_ SQQHL 381_ SANMF 386_ VALHS 391_ YSAHG 396_ PDELD 401_ LQKGE 406_ GVRVL 411_ GKCQD 416_ GWLRG 421_ VSLVT 426_ GRVGI 431_ FPNNY 436_ VIPIF 441_ RKTSS 446_ FPDSR 451_ SPGLY 456_ TTWTL 461_ STSSV 466_ SSQGS 471_ ISEGD 476_ PRQSR 481_ PFKSV 486_ FVPTA 491_ IVNPV 496_ RSTAG 501_ PGTLG 506_ QGSLR 511_ KGRSS 516_ MRKNG 521_ SLQRP 526_ LQSGI 531_ PTLVV 536_ GSLRR 541_ SPTMV 546_ LRPQQ 551_ FQFYQ 556_ PQGIP 561_ SSPSA 566_ VVVEM 571_ GSKPA 576_ LTGEP 581_ ALTCI 586_ SRGSE 591_ AWIHS 596_ AASSL 601_ IMEDK 606_ EIPIK 611_ SEPLP 616_ KPPAS 621_ APPSI 626_ LVKPE 631_ NSRNG 636_ IEKQV 641_ KTVRF 646_ QNYSP 651_ PPTKH 656_ YTSHP 661_ TSGKP 666_ EQPAT 671_ LKASQ 676_ PEAAS 681_ LGPEM 686_ TVLFA 691_ HRSGC 696_ HSGQQ 701_ TDLRR 706_ KSALG 711_ KATTL 716_ VSTAS 721_GTQTV
1: Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19389623, PubMed:19945436)