DENN domain-containing protein 1A (Connecdenn 1) (Connecdenn) (Protein FAM31A)
1_MGSRI 6_ KQNPE 11_ TTFEV 16_ YVEVA 21_ YPRTG 26_ GTLSD 31_ PEVQR 36_ QFPED 41_ YSDQE 46_ VLQTL 51_ TKFCF 56_ PFYVD 61_ SLTVS 66_ QVGQN 71_ FTFVL 76_ TDIDS 81_ KQRFG 86_ FCRLS 91_ SGAKS 96_ CFCIL 101_ SYLPW 106_ FEVFY 111_ KLLNI 116_ LADYT 121_ TKRQE 126_ NQWNE 131_ LLETL 136_ HKLPI 141_ PDPGV 146_ SVHLS 151_ VHSYF 156_ TVPDT 161_ RELPS 166_ IPENR 171_ NLTEY 176_ FVAVD 181_ VNNML 186_ HLYAS 191_ MLYER 196_ RILII 201_ CSKLS 206_ TLTAC 211_ IHGSA 216_ AMLYP 221_ MYWQH 226_ VYIPV 231_ LPPHL 236_ LDYCC 241_ APMPY 246_ LIGIH 251_ LSLME 256_ KVRNM 261_ ALDDV 266_ VILNV 271_ DTNTL 276_ ETPFD 281_ DLQSL 286_ PNDVI 291_ SSLKN 296_ RLKKV 301_ STTTG 306_ DGVAR 311_ AFLKA 316_ QAAFF 321_ GSYRN 326_ ALKIE 331_ PEEPI 336_ TFCEE 341_ AFVSH 346_ YRSGA 351_ MRQFL 356_ QNATQ 361_ LQLFK 366_ QFIDG 371_ RLDLL 376_ NSGEG 381_ FSDVF 386_ EEEIN 391_ MGEYA 396_ GSDKL 401_ YHQWL 406_ STVRK 411_ GSGAI 416_ LNTVK 421_ TKANP 426_ AMKTV 431_ YKFAK 436_ DHAKM 441_ GIKEV 446_ KNRLK 451_ QKDIA 456_ ENGCA 461_ PTPEE 466_ QLPKT 471_ APSPL 476_ VEAKD 481_ PKLRE 486_ DRRPI 491_ TVHFG 496_ QVRPP 501_ RPHVV 506_ KRPKS 511_ NIAVE 516_ GRRTS 521_ VPSPE 526_ QPQPY 531_ RTLRE 536_ SDSAE 541_ GDEAE 546_ SPEQQ 551_ VRKST 556_ GPVPA 561_ PPDRA 566_ ASIDL 571_ LEDVF 576_ SNLDM 581_ EAALQ 586_ PLGQA 591_ KSLED 596_ LRAPK 601_ DLREQ 606_ PGTFD 611_ YQRLD 616_ LGGSE 621_ RSRGV 626_ TVALK 631_ LTHPY 636_ NKLWS 641_ LGQDD 646_ MAIPS 651_ KPPAA 656_ SPEKP 661_ SALLG 666_ NSLAL 671_ PRRPQ 676_ NRDSI 681_ LNPSD 686_ KEEVP 691_ TPTLG 696_ SITIP 701_ RPQGR 706_ KTPEL 711_ GIVPP 716_ PPIPR 721_ PAKLQ 726_ AAGAA 731_ LGDVS 736_ ERLQT 741_ DRDRR 746_ AALSP 751_ GLLPG 756_ VVPQG 761_ PTELL 766_ QPLSP 771_ GPGAA 776_ GTSSD 781_ ALLAL 786_ LDPLS 791_ TAWSG 796_ STLPS 801_ RPATP 806_ NVATP 811_ FTPQF 816_ SFPPA 821_ GTPTP 826_ FPQPP 831_ LNPFV 836_ PSMPA 841_ APPTL 846_ PLVST 851_ PAGPF 856_ GAPPA 861_ SLGPA 866_ FASGL 871_ LLSSA 876_ GFCAP 881_ HRSQP 886_ NLSAL 891_ SMPNL 896_ FGQMP 901_ MGTHT 906_ SPLQP 911_ LGPPA 916_ VAPSR 921_ IRTLP 926_ LARSS 931_ ARAAE 936_ TKQGL 941_ ALRPG 946_ DPPLL 951_ PPRPP 956_ QGLEP 961_ TLQPS 966_ APQQA 971_ RDPFE 976_ DLLQK 981_ TKQDV 986_ SPSPA 991_ LAPAP 996_ DSVEQ 1001_LRKQW
1: Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity)