Gem-associated protein 5 (Gemin5)
1_MGQEP 6_ RTLPP 11_ SPNWY 16_ CARCS 21_ DAVPG 26_ GLFGF 31_ AARTS 36_ VFLVR 41_ VGPGA 46_ GESPG 51_ TPPFR 56_ VIGEL 61_ VGHTE 66_ RVSGF 71_ TFSHH 76_ PGQYN 81_ LCATS 86_ SDDGT 91_ VKIWD 96_ VETKT 101_ VVTEH 106_ ALHQH 111_ TISTL 116_ HWSPR 121_ VKDLI 126_ VSGDE 131_ KGVVF 136_ CYWFN 141_ RNDSQ 146_ HLFIE 151_ PRTIF 156_ CLTCS 161_ PHHED 166_ LVAIG 171_ YKDGI 176_ VVIID 181_ ISKKG 186_ EVIHR 191_ LRGHD 196_ DEIHS 201_ IAWCP 206_ LPGED 211_ CLSIN 216_ QEETS 221_ EEAEI 226_ TNGNA 231_ VAQAP 236_ VTKGC 241_ YLATG 246_ SKDQT 251_ IRIWS 256_ CSRGR 261_ GVMIL 266_ KLPFL 271_ KRRGG 276_ GIDPT 281_ VKERL 286_ WLTLH 291_ WPSNQ 296_ PTQLV 301_ SSCFG 306_ GELLQ 311_ WDLTQ 316_ SWRRK 321_ YTLFS 326_ ASSEG 331_ QNHSR 336_ IVFNL 341_ CPLQT 346_ EDDKQ 351_ LLLST 356_ SMDRD 361_ VKCWD 366_ IATLE 371_ CSWTL 376_ PSLGG 381_ FAYSL 386_ AFSSV 391_ DIGSL 396_ AIGVG 401_ DGMIR 406_ VWNTL 411_ SIKNN 416_ YDVKN 421_ FWQGV 426_ KSKVT 431_ ALCWH 436_ PTKEG 441_ CLAFG 446_ TDDGK 451_ VGLYD 456_ TYSNK 461_ PPQIS 466_ STYHK 471_ KTVYT 476_ LAWGP 481_ PVPPM 486_ SLGGE 491_ GDRPS 496_ LALYS 501_ CGGEG 506_ IVLQH 511_ NPWKL 516_ SGEAF 521_ DINKL 526_ IRDTN 531_ SIKYK 536_ LPVHT 541_ EISWK 546_ ADGKI 551_ MALGN 556_ EDGSI 561_ EIFQI 566_ PNLKL 571_ ICTIQ 576_ QHHKL 581_ VNTIS 586_ WHHEH 591_ GSQPE 596_ LSYLM 601_ ASGSN 606_ NAVIY 611_ VHNLK 616_ TVIES 621_ SPESP 626_ VTITE 631_ PYRTL 636_ SGHTA 641_ KITSV 646_ AWSPH 651_ HDGRL 656_ VSASY 661_ DGTAQ 666_ VWDAL 671_ REEPL 676_ CNFRG 681_ HRGRL 686_ LCVAW 691_ SPLDP 696_ DCIYS 701_ GADDF 706_ CVHKW 711_ LTSMQ 716_ DHSRP 721_ PQGKK 726_ SIELE 731_ KKRLS 736_ QPKAK 741_ PKKKK 746_ KPTLR 751_ TPVKL 756_ ESIDG 761_ NEEES 766_ MKENS 771_ GPVEN 776_ GVSDQ 781_ EGEEQ 786_ AREPE 791_ LPCGL 796_ APAVS 801_ REPVI 806_ CTPVS 811_ SGFEK 816_ SKVTI 821_ NNKVI 826_ LLKKE 831_ PPKEK 836_ PETLI 841_ KKRKA 846_ RSLLP 851_ LSTSL 856_ DHRSK 861_ EELHQ 866_ DCLVL 871_ ATAKH 876_ SRELN 881_ EDVSA 886_ DVEER 891_ FHLGL 896_ FTDRA 901_ TLYRM 906_ IDIEG 911_ KGHLE 916_ NGHPE 921_ LFHQL 926_ MLWKG 931_ DLKGV 936_ LQTAA 941_ ERGEL 946_ TDNLV 951_ AMAPA 956_ AGYHV 961_ WLWAV 966_ EAFAK 971_ QLCFQ 976_ DQYVK 981_ AASHL 986_ LSIHK 991_ VYEAV 996_ ELLKS 1001_ NHFYR 1006_ EAIAI 1011_ AKARL 1016_ RPEDP 1021_ VLKDL 1026_ YLSWG 1031_ TVLER 1036_ DGHYA 1041_ VAAKC 1046_ YLGAT 1051_ CAYDA 1056_ AKVLA 1061_ KKGDA 1066_ ASLRT 1071_ AAELA 1076_ AIVGE 1081_ DELSA 1086_ SLALR 1091_ CAQEL 1096_ LLANN 1101_ WVGAQ 1106_ EALQL 1111_ HESLQ 1116_ GQRLV 1121_ FCLLE 1126_ LLSRH 1131_ LEEKQ 1136_ LSEGK 1141_ SSSSY 1146_ HTWNT 1151_ GTEGP 1156_ FVERV 1161_ TAVWK 1166_ SIFSL 1171_ DTPEQ 1176_ YQEAF 1181_ QKLQN 1186_ IKYPS 1191_ ATNNT 1196_ PAKQL 1201_ LLHIC 1206_ HDLTL 1211_ AVLSQ 1216_ QMASW 1221_ DEAVQ 1226_ ALLRA 1231_ VVRSY 1236_ DSGSF 1241_ TIMQE 1246_ VYSAF 1251_ LPDGC 1256_ DHLRD 1261_ KLGDH 1266_ QSPAT 1271_ PAFKS 1276_ LEAFF 1281_ LYGRL 1286_ YEFWW 1291_ SLSRP 1296_ CPNSS 1301_ VWVRA 1306_ GHRTL 1311_ SVEPS 1316_ QQLDT 1321_ ASTEE 1326_ TDPET 1331_ SQPEP 1336_ NRPSE 1341_ LDLRL 1346_ TEEGE 1351_ RMLST 1356_ FKELF 1361_ SEKHA 1366_ SLQNS 1371_ QRTVA 1376_ EVQET 1381_ LAEMI 1386_ RQHQK 1391_ SQLCK 1396_ STANG 1401_ PDKNE 1406_ PEVEA 1411_ EQPLC 1416_ SSQSQ 1421_ CKEEK 1426_ NEPLS 1431_ LPELT 1436_ KRLTE 1441_ ANQRM 1446_ AKFPE 1451_ SIKAW 1456_ PFPDV 1461_ LECCL 1466_ VLLLI 1471_ RSHFP 1476_ GCLAQ 1481_ EMQQQ 1486_ AQELL 1491_ QKYGN 1496_ TKTYR 1501_RHCQT
1: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:16857593, PubMed:18984161, PubMed:20513430, PubMed:33963192). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate (PubMed:18984161). Binding of snRNA inside 5Sm ultimately triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. Within the SMN complex, GEMIN5 recognizes and delivers the small nuclear RNAs (snRNAs) to the SMN complex (PubMed:11714716, PubMed:16314521, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.27). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887)