Docking protein 4 (Downstream of tyrosine kinase 4) (Insulin receptor substrate 5) (IRS-5) (IRS5)
1_MATNF 6_ SDIVK 11_ QGYVK 16_ MKSRK 21_ LGIYR 26_ RCWLV 31_ FRKSS 36_ SKGPQ 41_ RLEKY 46_ PDEKS 51_ VCLRG 56_ CPKVT 61_ EISNV 66_ KCVTR 71_ LPKET 76_ KRQAV 81_ AIIFT 86_ DDSAR 91_ TFTCD 96_ SELEA 101_ EEWYK 106_ TLSVE 111_ CLGSR 116_ LNDIS 121_ LGEPD 126_ LLAPG 131_ VQCEQ 136_ TDRFN 141_ VFLLP 146_ CPNLD 151_ VYGEC 156_ KLQIT 161_ HENIY 166_ LWDIH 171_ NPRVK 176_ LVSWP 181_ LCSLR 186_ RYGRD 191_ ATRFT 196_ FEAGR 201_ MCDAG 206_ EGLYT 211_ FQTQE 216_ GEQIY 221_ QRVHS 226_ ATLAI 231_ AEQHK 236_ RVLLE 241_ MEKNV 246_ RLLNK 251_ GTEHY 256_ SYPCT 261_ PTTML 266_ PRSAY 271_ WHHIT 276_ GSQNI 281_ AEASS 286_ YAGEG 291_ YGAAQ 296_ ASSET 301_ DLLNR 306_ FILLK 311_ PKPSQ 316_ GDSSE 321_AKTPS
1: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells