Importin-4 (Imp4) (Importin-4b) (Imp4b) (Ran-binding protein 4) (RanBP4)
1_MESAG 6_ LEQLL 11_ RELLL 16_ PDTER 21_ IRRAT 26_ EQLQI 31_ VLRAP 36_ AALPA 41_ LCDLL 46_ ASAAD 51_ PQIRQ 56_ FAAVL 61_ TRRRL 66_ NTRWR 71_ RLAAE 76_ QRESL 81_ KSLIL 86_ TALQR 91_ ETEHC 96_ VSLSL 101_ AQLSA 106_ TIFRK 111_ EGLEA 116_ WPQLL 121_ QLLQH 126_ STHSP 131_ HSPER 136_ EMGLL 141_ LLSVV 146_ VTSRP 151_ EAFQP 156_ HHREL 161_ LRLLN 166_ ETLGE 171_ VGSPG 176_ LLFYS 181_ LRTLT 186_ TMAPY 191_ LSTED 196_ VPLAR 201_ MLVPK 206_ LIMAM 211_ QTLIP 216_ IDEAK 221_ ACEAL 226_ EALDE 231_ LLESE 236_ VPVIT 241_ PYLSE 246_ VLTFC 251_ LEVAR 256_ NVALG 261_ NAIRI 266_ RILCC 271_ LTFLV 276_ KVKSK 281_ ALLKN 286_ RLLPP 291_ LLHTL 296_ FPIVA 301_ AEPPP 306_ GQLDP 311_ EDQDS 316_ EEEEL 321_ EIELM 326_ GETPK 331_ HFAVQ 336_ VVDML 341_ ALHLP 346_ PEKLC 351_ PQLMP 356_ MLEEA 361_ LRSES 366_ PYQRK 371_ AGLLV 376_ LAVLS 381_ DGAGD 386_ HIRQR 391_ LLPPL 396_ LQIVC 401_ KGLED 406_ PSQVV 411_ RNAAL 416_ FALGQ 421_ FSENL 426_ QPHIS 431_ SYSRE 436_ VMPLL 441_ LAYLK 446_ SVPLG 451_ HTHHL 456_ AKACY 461_ ALENF 466_ VENLG 471_ PKVQP 476_ YLPEL 481_ MECML 486_ QLLRN 491_ PSSPR 496_ AKELA 501_ VSALG 506_ AIATA 511_ AQASL 516_ LPYFP 521_ AIMEH 526_ LREFL 531_ LTGRE 536_ DLQPV 541_ QIQSL 546_ ETLGV 551_ LARAV 556_ GEPMR 561_ PLAEE 566_ CCQLG 571_ LGLCD 576_ QVDDP 581_ DLRRC 586_ TYSLF 591_ AALSG 596_ LMGEG 601_ LAPHL 606_ EQITT 611_ LMLLS 616_ LRSTE 621_ GIVPQ 626_ YDGSS 631_ SFLLF 636_ DDESD 641_ GEEEE 646_ ELMDE 651_ DVEEE 656_ DDSEI 661_ SGYSV 666_ ENAFF 671_ DEKED 676_ TCAAV 681_ GEISV 686_ NTSVA 691_ FLPYM 696_ ESVFE 701_ EVFKL 706_ LECPH 711_ LNVRK 716_ AAHEA 721_ LGQFC 726_ CALHK 731_ ACQSC 736_ PSEPN 741_ TAALQ 746_ AALAR 751_ VVPSY 756_ MQAVN 761_ RERER 766_ QVVMA 771_ VLEAL 776_ TGVLR 781_ SCGTL 786_ TLKPP 791_ GRLAE 796_ LCGVL 801_ KAVLQ 806_ RKTAC 811_ QDTDE 816_ EEEEE 821_ DDDQA 826_ EYDAM 831_ LLEHA 836_ GEAIP 841_ ALAAA 846_ AGGDS 851_ FAPFF 856_ AGFLP 861_ LLVCK 866_ TKQGC 871_ TVAEK 876_ SFAVG 881_ TLAET 886_ IQGLG 891_ AASAQ 896_ FVSRL 901_ LPVLL 906_ STAQE 911_ ADPEV 916_ RSNAI 921_ FGMGV 926_ LAEHG 931_ GHPAQ 936_ EHFPK 941_ LLGLL 946_ FPLLA 951_ RERHD 956_ RVRDN 961_ ICGAL 966_ ARLLM 971_ ASPTR 976_ KPEPQ 981_ VLAAL 986_ LHALP 991_ LKEDL 996_ EEWVT 1001_ IGRLF 1006_ SFLYQ 1011_ SSPDQ 1016_ VIDVA 1021_ PELLR 1026_ ICSLI 1031_ LADNK 1036_ IPPDT 1041_ KAALL 1046_ LLLTF 1051_ LAKQH 1056_ TDSFQ 1061_ AALGS 1066_ LPVDK 1071_ AQELQ 1076_AVLGL
1: Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR (PubMed:11823430, PubMed:16207705, PubMed:17682055, PubMed:21454524). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430, PubMed:16207705). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430, PubMed:16207705). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B) (PubMed:21454524, PubMed:29408485). Mediates the ligand-independent nuclear import of vitamin D receptor (VDR) (PubMed:16207705). In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS (PubMed:12610148)