Ubiquitin carboxyl-terminal hydrolase 33 (EC 3.4.19.12) (Deubiquitinating enzyme 33) (Ubiquitin thioesterase 33) (Ubiquitin-specific-processing protease 33) (VHL-interacting deubiquitinating enzyme 1) (hVDU1)
1_MTGSN 6_ SHITI 11_ LTLKV 16_ LPHFE 21_ SLGKQ 26_ EKIPN 31_ KMSAF 36_ RNHCP 41_ HLDSV 46_ GEITK 51_ EDLIQ 56_ KSLGT 61_ CQDCK 66_ VQGPN 71_ LWACL 76_ ENRCS 81_ YVGCG 86_ ESQVD 91_ HSTIH 96_ SQETK 101_ HYLTV 106_ NLTTL 111_ RVWCY 116_ ACSKE 121_ VFLDR 126_ KLGTQ 131_ PSLPH 136_ VRQPH 141_ QIQEN 146_ SVQDF 151_ KIPSN 156_ TTLKT 161_ PLVAV 166_ FDDLD 171_ IEADE 176_ EDELR 181_ ARGLT 186_ GLKNI 191_ GNTCY 196_ MNAAL 201_ QALSN 206_ CPPLT 211_ QFFLD 216_ CGGLA 221_ RTDKK 226_ PAICK 231_ SYLKL 236_ MTELW 241_ HKSRP 246_ GSVVP 251_ TTLFQ 256_ GIKTV 261_ NPTFR 266_ GYSQQ 271_ DAQEF 276_ LRCLM 281_ DLLHE 286_ ELKEQ 291_ VMEVE 296_ EDPQT 301_ ITTEE 306_ TMEED 311_ KSQSD 316_ VDFQS 321_ CESCS 326_ NSDRA 331_ ENENG 336_ SRCFS 341_ EDNNE 346_ TTMLI 351_ QDDEN 356_ NSEMS 361_ KDWQK 366_ EKMCN 371_ KINKV 376_ NSEGE 381_ FDKDR 386_ DSISE 391_ TVDLN 396_ NQETV 401_ KVQIH 406_ SRASE 411_ YITDV 416_ HSNDL 421_ STPQI 426_ LPSNE 431_ GVNPR 436_ LSASP 441_ PKSGN 446_ LWPGL 451_ APPHK 456_ KAQSA 461_ SPKRK 466_ KQHKK 471_ YRSVI 476_ SDIFD 481_ GTIIS 486_ SVQCL 491_ TCDRV 496_ SVTLE 501_ TFQDL 506_ SLPIP 511_ GKEDL 516_ AKLHS 521_ SSHPT 526_ SIVKA 531_ GSCGE 536_ AYAPQ 541_ GWIAF 546_ FMEYV 551_ KRFVV 556_ SCVPS 561_ WFWGP 566_ VVTLQ 571_ DCLAA 576_ FFARD 581_ ELKGD 586_ NMYSC 591_ EKCKK 596_ LRNGV 601_ KFCKV 606_ QNFPE 611_ ILCIH 616_ LKRFR 621_ HELMF 626_ STKIS 631_ THVSF 636_ PLEGL 641_ DLQPF 646_ LAKDS 651_ PAQIV 656_ TYDLL 661_ SVICH 666_ HGTAS 671_ SGHYI 676_ AYCRN 681_ NLNNL 686_ WYEFD 691_ DQSVT 696_ EVSES 701_ TVQNA 706_ EAYVL 711_ FYRKS 716_ SEEAQ 721_ KERRR 726_ ISNLL 731_ NIMEP 736_ SLLQF 741_ YISRQ 746_ WLNKF 751_ KTFAE 756_ PGPIS 761_ NNDFL 766_ CIHGG 771_ VPPRK 776_ AGYIE 781_ DLVLM 786_ LPQNI 791_ WDNLY 796_ SRYGG 801_ GPAVN 806_ HLYIC 811_ HTCQI 816_ EAEKI 821_ EKRRK 826_ TELEI 831_ FIRLN 836_ RAFQK 841_ EDSPA 846_ TFYCI 851_ SMQWF 856_ REWES 861_ FVKGK 866_ DGDPP 871_ GPIDN 876_ TKIAV 881_ TKCGN 886_ VMLRQ 891_ GADSG 896_ QISEE 901_ TWNFL 906_ QSIYG 911_ GGPEV 916_ ILRPP 921_ VVHVD 926_ PDILQ 931_ AEEKI 936_EVETR
1: Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains