WASP homolog-associated protein with actin, membranes and microtubules (WAS protein homology region 2 domain-containing protein 1) (WH2 domain-containing protein 1)
1_MEDEQ 6_ PDSLE 11_ GWVPV 16_ REGLF 21_ AEPER 26_ HRLRF 31_ LVAWN 36_ GAEGK 41_ FAVTC 46_ HDRTA 51_ QQRRL 56_ REGAR 61_ LGPEP 66_ EPKPE 71_ AAVSP 76_ SSWAG 81_ LLSAA 86_ GLRGA 91_ HRQLA 96_ ALWPP 101_ LERCF 106_ PRLPP 111_ ELDVG 116_ GGGAW 121_ GLGLG 126_ LWALL 131_ WPTRA 136_ GPGEA 141_ ALQEL 146_ CGQLE 151_ RYLGA 156_ AADGC 161_ GGATV 166_ RDALF 171_ PAEGG 176_ AADCE 181_ SPREF 186_ RERAL 191_ RARWV 196_ EADAR 201_ LRQVI 206_ QGHGK 211_ ANTMV 216_ ALMNV 221_ YQEED 226_ EAYQE 231_ LVTVA 236_ TMFFQ 241_ YLLQP 246_ FRAMR 251_ EVATL 256_ CKLDI 261_ LKSLD 266_ EDDLG 271_ PRRVV 276_ ALEKE 281_ AEEWT 286_ RRAEE 291_ AVVSI 296_ QDITV 301_ NYFKE 306_ TVKAL 311_ AGMQK 316_ EMEQD 321_ AKRFG 326_ QAAWA 331_ TAIPR 336_ LEKLQ 341_ LMLAR 346_ ETLQL 351_ MRAKE 356_ LCLNH 361_ KRAEI 366_ QGKME 371_ DLPEQ 376_ EKNTN 381_ VVDEL 386_ EIQFY 391_ EIQLE 396_ LYEVK 401_ FEILK 406_ NEEIL 411_ LTTQL 416_ DSLKR 421_ LIKEK 426_ QDEVV 431_ YYDPC 436_ ENPEE 441_ LKVID 446_ CVVGL 451_ QDDKN 456_ LEVKE 461_ LRRQC 466_ QQLES 471_ KRGRI 476_ CAKRA 481_ SLRSR 486_ KDQCK 491_ ENHRF 496_ RLQQA 501_ EESIR 506_ YSRQH 511_ HSIQM 516_ KRDKI 521_ KEEEQ 526_ KKKEW 531_ INQER 536_ QKTLQ 541_ RLRSF 546_ KDKRL 551_ AQSVR 556_ NTSGS 561_ EPVAP 566_ NLPSD 571_ LSQQM 576_ CLPAS 581_ HAVSV 586_ IHPSS 591_ RKTRG 596_ VPLSE 601_ AGNVK 606_ SPKCQ 611_ NCHGN 616_ IPVQV 621_ FVPVG 626_ DQTHS 631_ KSSEE 636_ LSLPP 641_ PPPPP 646_ PPPPP 651_ PPPPP 656_ PPPLR 661_ ALSSS 666_ SQAAT 671_ HQNLG 676_ FRAPV 681_ KDDQP 686_ RPLVC 691_ ESPAE 696_ RPRDS 701_ LESFS 706_ CPGSM 711_ DEVLA 716_ SLRHG 721_ RAPLR 726_ KVEVP 731_ AVRPP 736_ HASIN 741_ EHILA 746_ AIRQG 751_ VKLKK 756_ VHPDL 761_ GPNPS 766_ SKPTS 771_ NRRTS 776_ DLERS 781_ IKAAL 786_ QRIKR 791_ VSADS 796_ EEDSD 801_EQDPG
1: Acts as a nucleation-promoting factor (NPF) that stimulates Arp2/3-mediated actin polymerization both at the Golgi apparatus and along tubular membranes. Its activity in membrane tubulation requires F-actin and interaction with microtubules. Proposed to use coordinated actin-nucleating and microtubule-binding activities of distinct WHAMM molecules to drive membrane tubule elongation; when MT-bound can recruit and remodel membrane vesicles but is prevented to activate the Arp2/3 complex. Involved as a regulator of Golgi positioning and morphology. Participates in vesicle transport between the reticulum endoplasmic and the Golgi complex. Required for RhoD-dependent actin reorganization such as in cell adhesion and cell migration