Folliculin-interacting protein 1
1_MAPTL 6_ FQKLF 11_ SKRTG 16_ LGAPG 21_ RDARD 26_ PDCGF 31_ SWPLP 36_ EFDPS 41_ QIRLI 46_ VYQDC 51_ ERRGR 56_ NVLFD 61_ SSVKR 66_ RNEDI 71_ SVSKL 76_ GSDAQ 81_ VKVFG 86_ KCCQL 91_ KPGGD 96_ SSSSL 101_ DSSVT 106_ SSSDI 111_ KDQCL 116_ KYQGS 121_ RCSSD 126_ ANMLG 131_ EMMFG 136_ SVAMS 141_ YKGST 146_ LKIHQ 151_ IRSPP 156_ QLMLS 161_ KVFTA 166_ RTGSS 171_ ICGSL 176_ NTLQD 181_ SLEFI 186_ NQDNN 191_ TLKAD 196_ NNTVI 201_ NGLLG 206_ NIGLS 211_ QFCSP 216_ RRAFS 221_ EQGPL 226_ RLIRS 231_ ASFFA 236_ VHSNP 241_ MDMPG 246_ RELNE 251_ DRDSG 256_ IARSA 261_ SLSSL 266_ LITPF 271_ PSPNS 276_ SLTRS 281_ CASSY 286_ QRRWR 291_ RSQTT 296_ SLENG 301_ VFPRW 306_ SIEES 311_ FNLSD 316_ ESCGP 321_ NPGIV 326_ RKKKI 331_ AIGVI 336_ FSLSK 341_ DEDEN 346_ NKFNE 351_ FFFSH 356_ FPLFE 361_ SHMNK 366_ LKSAI 371_ EQAMK 376_ MSRRS 381_ ADASQ 386_ RSLAY 391_ NRIVD 396_ ALNEF 401_ RTTIC 406_ NLYTM 411_ PRIGE 416_ PVWLT 421_ MMSGT 426_ PEKNH 431_ LCYRF 436_ MKEFT 441_ FLMEN 446_ ASKNQ 451_ FLPAL 456_ ITAVL 461_ TNHLA 466_ WVPTV 471_ MPNGQ 476_ PPIKI 481_ FLEKH 486_ SSQSV 491_ DMLAK 496_ THPYN 501_ PLWAQ 506_ LGDLY 511_ GAIGS 516_ PVRLA 521_ RTVVV 526_ GKRQD 531_ MVQRL 536_ LYFLT 541_ YFIRC 546_ SELQE 551_ THLLE 556_ NGEDE 561_ AIVMP 566_ GTVIT 571_ TTLEK 576_ GEIEE 581_ SEYVL 586_ VTMHR 591_ NKSSL 596_ LFKES 601_ EEIRT 606_ PNCNC 611_ KYCSH 616_ PLLGQ 621_ NVENI 626_ SQQER 631_ EDIQN 636_ SSKEL 641_ LGISD 646_ ECQMI 651_ SPSDC 656_ QEENA 661_ VDVKQ 666_ YRDKL 671_ RTCFD 676_ AKLET 681_ VVCTG 686_ SVPVD 691_ KCALS 696_ ESGLE 701_ STEET 706_ WQSEK 711_ LLDSD 716_ SHTGK 721_ AMRST 726_ GMVVE 731_ KKPPD 736_ KIVPA 741_ SFSCE 746_ AAQTK 751_ VTFLI 756_ GDSMS 761_ PDSDT 766_ ELRSQ 771_ AVVDQ 776_ ITRHH 781_ TKPLK 786_ EERGA 791_ IDQHQ 796_ ETKQT 801_ TKDQS 806_ GESDT 811_ QNMVS 816_ EEPCE 821_ LPCWN 826_ HSDPE 831_ SMSLF 836_ DEYFN 841_ DDSIE 846_ TRTID 851_ DVPFK 856_ TSTDS 861_ KDHCC 866_ MLEFS 871_ KILCT 876_ KNNKQ 881_ NNEFC 886_ KCIET 891_ VPQDS 896_ CKTCF 901_ PQQDQ 906_ RDTLS 911_ ILVPH 916_ GDKES 921_ SDKKI 926_ AVGTE 931_ WDIPR 936_ NESSD 941_ SALGD 946_ SESED 951_ TGHDM 956_ TRQVS 961_ SYYGG 966_ EQEDW 971_ AEEDE 976_ IPFPG 981_ SKLIE 986_ VSAVQ 991_ PNIAN 996_ FGRSL 1001_ LGGYC 1006_ SSYVP 1011_ DFVLQ 1016_ GIGSD 1021_ ERFRQ 1026_ CLMSD 1031_ LSHAV 1036_ QHPVL 1041_ DEPIA 1046_ EAVCI 1051_ IADMD 1056_ KWTVQ 1061_ VASSQ 1066_ RRVTD 1071_ NKLGK 1076_ EVLVS 1081_ SLVSN 1086_ LLHST 1091_ LQLYK 1096_ HNLSP 1101_ NFCVM 1106_ HLEDR 1111_ LQELY 1116_ FKSKM 1121_ LSEYL 1126_ RGQMR 1131_ VHVKE 1136_ LGVVL 1141_ GIESS 1146_ DLPLL 1151_ AAVAS 1156_ THSPY 1161_VAQIL
1: Binding partner of the GTPase-activating protein FLCN: involved in the cellular response to amino acid availability by regulating the non-canonical mTORC1 signaling cascade controlling the MiT/TFE factors TFEB and TFE3 (PubMed:17028174, PubMed:18663353, PubMed:24081491, PubMed:37079666). Required to promote FLCN recruitment to lysosomes and interaction with Rag GTPases, leading to activation of the non-canonical mTORC1 signaling (PubMed:24081491). In low-amino acid conditions, component of the lysosomal folliculin complex (LFC) on the membrane of lysosomes, which inhibits the GTPase-activating activity of FLCN, thereby inactivating mTORC1 and promoting nuclear translocation of TFEB and TFE3 (By similarity). Upon amino acid restimulation, disassembly of the LFC complex liberates the GTPase-activating activity of FLCN, leading to activation of mTORC1 and subsequent inactivation of TFEB and TFE3 (PubMed:37079666). Together with FLCN, regulates autophagy: following phosphorylation by ULK1, interacts with GABARAP and promotes autophagy (PubMed:25126726). In addition to its role in mTORC1 signaling, also acts as a co-chaperone of HSP90AA1/Hsp90: following gradual phosphorylation by CK2, inhibits the ATPase activity of HSP90AA1/Hsp90, leading to activate both kinase and non-kinase client proteins of HSP90AA1/Hsp90 (PubMed:27353360, PubMed:30699359). Acts as a scaffold to load client protein FLCN onto HSP90AA1/Hsp90 (PubMed:27353360). Competes with the activating co-chaperone AHSA1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins (PubMed:27353360). Also acts as a core component of the reductive stress response by inhibiting activation of mitochondria in normal conditions: in response to reductive stress, the conserved Cys degron is reduced, leading to recognition and polyubiquitylation by the CRL2(FEM1B) complex, followed by proteasomal (By similarity). Required for B-cell development (PubMed:32905580)