Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2)
1_MAQYG 6_ HPSPL 11_ GMAAR 16_ EELYS 21_ KVTPR 26_ RNRQQ 31_ RPGTI 36_ KHGSA 41_ LDVLL 46_ SMGFP 51_ RARAQ 56_ KALAS 61_ TGGRS 66_ VQAAC 71_ DWLFS 76_ HVGDP 81_ FLDDP 86_ LPREY 91_ VLYLR 96_ PTGPL 101_ AQKLS 106_ DFWQQ 111_ SKQIC 116_ GKNKA 121_ HNIFP 126_ HITLC 131_ QFFMC 136_ EDSKV 141_ DALGE 146_ ALQTT 151_ VSRWK 156_ CKFSA 161_ PLPLE 166_ LYTSS 171_ NFIGL 176_ FVKED 181_ SAEVL 186_ KKFAA 191_ DFAAE 196_ AASKT 201_ EVHVE 206_ PHKKQ 211_ LHVTL 216_ AYHFQ 221_ ASHLP 226_ TLEKL 231_ AQNID 236_ VKLGC 241_ DWVAT 246_ IFSRD 251_ IRFAN 256_ HETLQ 261_ VIYPY 266_ TPQND 271_ DELEL 276_ VPGDF 281_ IFMSP 286_ MEQTS 291_ TSEGW 296_ IYGTS 301_ LTTGC 306_ SGLLP 311_ ENYIT 316_ KADEC 321_ STWIF 326_ HGSYS 331_ ILNTS 336_ SSNSL 341_ TFGDG 346_ VLERR 351_ PYEDQ 356_ GLGET 361_ TPLTI 366_ ICQPM 371_ QPLRV 376_ NSQPG 381_ PQKRC 386_ LFVCR 391_ HGERM 396_ DVVFG 401_ KYWLS 406_ QCFDA 411_ KGRYI 416_ RTNLN 421_ MPHSL 426_ PQRSG 431_ GFRDY 436_ EKDAP 441_ ITVFG 446_ CMQAR 451_ LVGEA 456_ LLESN 461_ TIIDH 466_ VYCSP 471_ SLRCV 476_ QTAHN 481_ ILKGL 486_ QQENH 491_ LKIRV 496_ EPGLF 501_ EWTKW 506_ VAGST 511_ LPAWI 516_ PPSEL 521_ AAANL 526_ SVDTT 531_ YRPHI 536_ PISKL 541_ VVSES 546_ YDTYI 551_ SRSFQ 556_ VTKEI 561_ ISECK 566_ SKGNN 571_ ILIVA 576_ HASSL 581_ EACTC 586_ QLQGL 591_ SPQNS 596_ KDFVQ 601_ MVRKI 606_ PYLGF 611_ CSCEE 616_ LGETG 621_ IWQLT 626_ DPPIL 631_ PLTHG 636_ PTGGF 641_NWRET
1: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination