DIS3-like exonuclease 1 (EC 3.1.13.-)
1_MLQKR 6_ EKVLL 11_ LRTFQ 16_ GRTLR 21_ IVREH 26_ YLRPC 31_ VPCHS 36_ PLCPQ 41_ PAACS 46_ HDGKL 51_ LSSDV 56_ THYVI 61_ PDWKV 66_ VQDYL 71_ EILEF 76_ PELKG 81_ IIFMQ 86_ TACQA 91_ VQHQR 96_ GRRQY 101_ NKLRN 106_ LLKDA 111_ RHDCI 116_ LFANE 121_ FQQCC 126_ YLPRE 131_ RGESM 136_ EKWQT 141_ RSIYN 146_ AAVWY 151_ YHHCQ 156_ DRMPI 161_ VMVTE 166_ DEEAI 171_ QQYGS 176_ ETEGV 181_ FVITF 186_ KNYLD 191_ NFWPD 196_ LKAAH 201_ ELCDS 206_ ILQSR 211_ REREN 216_ ESQES 221_ HGKEY 226_ PEHLP 231_ LEVLE 236_ AGIKS 241_ GRYIQ 246_ GILNV 251_ NKHRA 256_ QIEAF 261_ VRLQG 266_ ASSKD 271_ SDLVS 276_ DILIH 281_ GMKAR 286_ NRSIH 291_ GDVVV 296_ VELLP 301_ KNEWK 306_ GRTVA 311_ LCEND 316_ CDDKA 321_ SGESP 326_ SEPMP 331_ TGRVV 336_ GILQK 341_ NWRDY 346_ VVTFP 351_ SKEEV 356_ QSQGK 361_ NAQKI 366_ LVTPW 371_ DYRIP 376_ KIRIS 381_ TQQAE 386_ TLQDF 391_ RVVVR 396_ IDSWE 401_ STSVY 406_ PNGHF 411_ VRVLG 416_ RIGDL 421_ EGEIA 426_ TILVE 431_ NSISV 436_ IPFSE 441_ AQMCE 446_ MPVNT 451_ PESPW 456_ KVSPE 461_ EEQKR 466_ KDLRK 471_ SHLVF 476_ SIDPK 481_ GCEDV 486_ DDTLS 491_ VRTLN 496_ NGNLE 501_ LGVHI 506_ ADVTH 511_ FVAPN 516_ SYIDI 521_ EARTR 526_ ATTYY 531_ LADRR 536_ YDMLP 541_ SVLSA 546_ DLCSL 551_ LGGVD 556_ RYAVS 561_ IMWEL 566_ DKASY 571_ EIKKV 576_ WYGRT 581_ IIRSA 586_ YKLFY 591_ EAAQE 596_ LLDGN 601_ LSVVD 606_ DIPEF 611_ KDLDE 616_ KSRQA 621_ KLEEL 626_ VWAIG 631_ KLTDI 636_ ARHVR 641_ AKRDG 646_ CGALE 651_ LEGVE 656_ VCVQL 661_ DDKKN 666_ IHDLI 671_ PKQPL 676_ EVHET 681_ VAECM 686_ ILANH 691_ WVAKK 696_ IWESF 701_ PHQAL 706_ LRQHP 711_ PPHQE 716_ FFSEL 721_ RECAK 726_ AKGFF 731_ IDTRS 736_ NKTLA 741_ DSLDN 746_ ANDPH 751_ DPIVN 756_ RLLRS 761_ MATQA 766_ MSNAL 771_ YFSTG 776_ SCAEE 781_ EFHHY 786_ GLALD 791_ KYTHF 796_ TSPIR 801_ RYSDI 806_ VVHRL 811_ LMAAI 816_ SKDKK 821_ MEIKG 826_ NLFSN 831_ KDLEE 836_ LCRHI 841_ NNRNQ 846_ AAQHS 851_ QKQST 856_ ELFQC 861_ MYFKD 866_ KDPAT 871_ EERCI 876_ SDGVI 881_ YSIRT 886_ NGVLL 891_ FIPRF 896_ GIKGA 901_ AYLKN 906_ KDGLV 911_ ISCGP 916_ DSCSE 921_ WKPGS 926_ LQRFQ 931_ NKITS 936_ TTTDG 941_ ESVTF 946_ HLFDH 951_ VTVRI 956_ SIQAS 961_ RCHSD 966_ TIRLE 971_ IISNK 976_ PYKIP 981_ NTELI 986_ HQSSP 991_ LLKSE 996_ LVKEV 1001_ TKSVE 1006_ EAQLA 1011_ QEVKV 1016_ NIIQE 1021_ EYQEY 1026_ RQTKG 1031_ RSLYT 1036_ LLEEI 1041_ RDLAL 1046_LDVSN
1: Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (PubMed:20531386, PubMed:20531389, PubMed:37602378). In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA (PubMed:20531386, PubMed:20531389)