Probable phospholipid-transporting ATPase IM (EC 7.6.2.1) (ATPase class I type 8B member 4) (P4-ATPase flippase complex alpha subunit ATP8B4)
1_MFCSE 6_ KKLRE 11_ VERIV 16_ KANDR 21_ EYNEK 26_ FQYAD 31_ NRIHT 36_ SKYNI 41_ LTFLP 46_ INLFE 51_ QFQRV 56_ ANAYF 61_ LCLLI 66_ LQLIP 71_ EISSL 76_ TWFTT 81_ IVPLV 86_ LVITM 91_ TAVKD 96_ ATDDY 101_ FRHKS 106_ DNQVN 111_ NRQSE 116_ VLINS 121_ KLQNE 126_ KWMNV 131_ KVGDI 136_ IKLEN 141_ NQFVA 146_ ADLLL 151_ LSSSE 156_ PHGLC 161_ YVETA 166_ ELDGE 171_ TNLKV 176_ RHALS 181_ VTSEL 186_ GADIS 191_ RLAGF 196_ DGIVV 201_ CEVPN 206_ NKLDK 211_ FMGIL 216_ SWKDS 221_ KHSLN 226_ NEKII 231_ LRGCI 236_ LRNTS 241_ WCFGM 246_ VIFAG 251_ PDTKL 256_ MQNSG 261_ KTKFK 266_ RTSID 271_ RLMNT 276_ LVLWI 281_ FGFLI 286_ CLGII 291_ LAIGN 296_ SIWES 301_ QTGDQ 306_ FRTFL 311_ FWNEG 316_ EKSSV 321_ FSGFL 326_ TFWSY 331_ IIILN 336_ TVVPI 341_ SLYVS 346_ VEVIR 351_ LGHSY 356_ FINWD 361_ RKMYY 366_ SRKAI 371_ PAVAR 376_ TTTLN 381_ EELGQ 386_ IEYIF 391_ SDKTG 396_ TLTQN 401_ IMTFK 406_ RCSIN 411_ GRIYG 416_ EVHDD 421_ LDQKT 426_ EITQE 431_ KEPVD 436_ FSVKS 441_ QADRE 446_ FQFFD 451_ HHLME 456_ SIKMG 461_ DPKVH 466_ EFLRL 471_ LALCH 476_ TVMSE 481_ ENSAG 486_ ELIYQ 491_ VQSPD 496_ EGALV 501_ TAARN 506_ FGFIF 511_ KSRTP 516_ ETITI 521_ EELGT 526_ LVTYQ 531_ LLAFL 536_ DFNNT 541_ RKRMS 546_ VIVRN 551_ PEGQI 556_ KLYSK 561_ GADTI 566_ LFEKL 571_ HPSNE 576_ VLLSL 581_ TSDHL 586_ SEFAG 591_ EGLRT 596_ LAIAY 601_ RDLDD 606_ KYFKE 611_ WHKML 616_ EDANA 621_ ATEER 626_ DERIA 631_ GLYEE 636_ IERDL 641_ MLLGA 646_ TAVED 651_ KLQEG 656_ VIETV 661_ TSLSL 666_ ANIKI 671_ WVLTG 676_ DKQET 681_ AINIG 686_ YACNM 691_ LTDDM 696_ NDVFV 701_ IAGNN 706_ AVEVR 711_ EELRK 716_ AKQNL 721_ FGQNR 726_ NFSNG 731_ HVVCE 736_ KKQQL 741_ ELDSI 746_ VEETI 751_ TGDYA 756_ LIING 761_ HSLAH 766_ ALESD 771_ VKNDL 776_ LELAC 781_ MCKTV 786_ ICCRV 791_ TPLQK 796_ AQVVE 801_ LVKKY 806_ RNAVT 811_ LAIGD 816_ GANDV 821_ SMIKS 826_ AHIGV 831_ GISGQ 836_ EGLQA 841_ VLASD 846_ YSFAQ 851_ FRYLQ 856_ RLLLV 861_ HGRWS 866_ YFRMC 871_ KFLCY 876_ FFYKN 881_ FAFTL 886_ VHFWF 891_ GFFCG 896_ FSAQT 901_ VYDQW 906_ FITLF 911_ NIVYT 916_ SLPVL 921_ AMGIF 926_ DQDVS 931_ DQNSV 936_ DCPQL 941_ YKPGQ 946_ LNLLF 951_ NKRKF 956_ FICVL 961_ HGIYT 966_ SLVLF 971_ FIPYG 976_ AFYNV 981_ AGEDG 986_ QHIAD 991_ YQSFA 996_ VTMAT 1001_ SLVIV 1006_ VSVQI 1011_ ALDTS 1016_ YWTFI 1021_ NHVFI 1026_ WGSIA 1031_ IYFSI 1036_ LFTMH 1041_ SNGIF 1046_ GIFPN 1051_ QFPFV 1056_ GNARH 1061_ SLTQK 1066_ CIWLV 1071_ ILLTT 1076_ VASVM 1081_ PVVAF 1086_ RFLKV 1091_ DLYPT 1096_ LSDQI 1101_ RRWQK 1106_ AQKKA 1111_ RPPSS 1116_ RRPRT 1121_ RRSSS 1126_ RRSGY 1131_ AFAHQ 1136_ EGYGE 1141_ LITSG 1146_ KNMRA 1151_ KNPPP 1156_ TSGLE 1161_ KTHYN 1166_ STSWI 1171_ ENLCK 1176_ KTTDT 1181_ VSSFS 1186_QDKTV
1: Component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable)