Apoptosis-enhancing nuclease (EC 3.1.-.-) (Interferon-stimulated 20 kDa exonuclease-like 1)
1_MVPRE 6_ APESA 11_ QCLCP 16_ SLTIP 21_ NAKDV 26_ LRKRH 31_ KRRSR 36_ QHQRF 41_ MARKA 46_ LLQEQ 51_ GLLSM 56_ PPEPG 61_ SSPLP 66_ TPFGA 71_ ATATE 76_ AASSG 81_ KQCLR 86_ AGSGS 91_ APCSR 96_ RPAPG 101_ KASGP 106_ LPSKC 111_ VAIDC 116_ EMVGT 121_ GPRGR 126_ VSELA 131_ RCSIV 136_ SYHGN 141_ VLYDK 146_ YIRPE 151_ MPIAD 156_ YRTRW 161_ SGITR 166_ QHMRK 171_ AVPFQ 176_ VAQKE 181_ ILKLL 186_ KGKVV 191_ VGHAL 196_ HNDFQ 201_ ALKYV 206_ HPRSQ 211_ TRDTT 216_ YVPNF 221_ LSEPG 226_ LHTRA 231_ RVSLK 236_ DLALQ 241_ LLHKK 246_ IQVGQ 251_ HGHSS 256_ VEDAT 261_ TAMEL 266_ YRLVE 271_ VQWEQ 276_ QEARS 281_ LWTCP 286_ EDREP 291_ DSSTD 296_ MEQYM 301_ EDQYW 306_ PDDLA 311_ HGSRG 316_GAREA
1: Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis