1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (EC 2.3.1.51) (Abhydrolase domain-containing protein 5) (Lipid droplet-binding protein CGI-58)
1_MAAEE 6_ EEVDS 11_ ADTGE 16_ RSGWL 21_ TGWLP 26_ TWCPT 31_ SISHL 36_ KEAEE 41_ KMLKC 46_ VPCTY 51_ KKEPV 56_ RISNG 61_ NKIWT 66_ LKFSH 71_ NISNK 76_ TPLVL 81_ LHGFG 86_ GGLGL 91_ WALNF 96_ GDLCT 101_ NRPVY 106_ AFDLL 111_ GFGRS 116_ SRPRF 121_ DSDAE 126_ EVENQ 131_ FVESI 136_ EEWRC 141_ ALGLD 146_ KMILL 151_ GHNLG 156_ GFLAA 161_ AYSLK 166_ YPSRV 171_ NHLIL 176_ VEPWG 181_ FPERP 186_ DLADQ 191_ DRPIP 196_ VWIRA 201_ LGAAL 206_ TPFNP 211_ LAGLR 216_ IAGPF 221_ GLSLV 226_ QRLRP 231_ DFKRK 236_ YSSMF 241_ EDDTV 246_ TEYIY 251_ HCNVQ 256_ TPSGE 261_ TAFKN 266_ MTIPY 271_ GWAKR 276_ PMLQR 281_ IGKMH 286_ PDIPV 291_ SVIFG 296_ ARSCI 301_ DGNSG 306_ TSIQS 311_ LRPHS 316_ YVKTI 321_ AILGA 326_ GHYVY 331_ ADQPE 336_ EFNQK 341_VKEIC
1: Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid (PubMed:18606822). Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (PubMed:18606822). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (PubMed:16679289). Involved in keratinocyte differentiation (PubMed:18832586). Regulates lipid droplet fusion (By similarity)