Histone-lysine N-methyltransferase SETD7 (EC 2.1.1.364) (Histone H3-K4 methyltransferase SETD7) (H3-K4-HMTase SETD7) (Lysine N-methyltransferase 7) (SET domain-containing protein 7) (SET7/9)
1_MDSDD 6_ EMVEE 11_ AVEGH 16_ LDDDG 21_ LPHGF 26_ CTVTY 31_ SSTDR 36_ FEGNF 41_ VHGEK 46_ NGRGK 51_ FFFFD 56_ GSTLE 61_ GYYVD 66_ DALQG 71_ QGVYT 76_ YEDGG 81_ VLQGT 86_ YVDGE 91_ LNGPA 96_ QEYDT 101_ DGRLI 106_ FKGQY 111_ KDNIR 116_ HGVCW 121_ IYYPD 126_ GGSLV 131_ GEVNE 136_ DGEMT 141_ GEKIA 146_ YVYPD 151_ ERTAL 156_ YGKFI 161_ DGEMI 166_ EGKLA 171_ TLMST 176_ EEGRP 181_ HFELM 186_ PGNSV 191_ YHFDK 196_ STSSC 201_ ISTNA 206_ LLPDP 211_ YESER 216_ VYVAE 221_ SLISS 226_ AGEGL 231_ FSKVA 236_ VGPNT 241_ VMSFY 246_ NGVRI 251_ THQEV 256_ DSRDW 261_ ALNGN 266_ TLSLD 271_ EETVI 276_ DVPEP 281_ YNHVS 286_ KYCAS 291_ LGHKA 296_ NHSFT 301_ PNCIY 306_ DMFVH 311_ PRFGP 316_ IKCIR 321_ TLRAV 326_ EADEE 331_ LTVAY 336_ GYDHS 341_ PPGKS 346_ GPEAP 351_ EWYQV 356_ ELKAF 361_QATQQ
1: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3 (PubMed:11779497, PubMed:11850410, PubMed:12540855, PubMed:12588998, PubMed:16141209). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:12540855, PubMed:12588998, PubMed:16141209). Plays a central role in the transcriptional activation of genes such as collagenase or insulin (PubMed:12588998, PubMed:16141209). Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription (PubMed:16141209). Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins (PubMed:15099517, PubMed:15525938, PubMed:16415881, PubMed:35210392). Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II (PubMed:15099517, PubMed:16415881). Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation (PubMed:15525938, PubMed:16415881, PubMed:17108971). Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS (By similarity)