C-type lectin domain family 4 member C (Blood dendritic cell antigen 2) (BDCA-2) (C-type lectin superfamily member 7) (Dendritic lectin) (CD antigen CD303)
1_MVPEE 6_ EPQDR 11_ EKGLW 16_ WFQLK 21_ VWSMA 26_ VVSIL 31_ LLSVC 36_ FTVSS 41_ VVPHN 46_ FMYSK 51_ TVKRL 56_ SKLRE 61_ YQQYH 66_ PSLTC 71_ VMEGK 76_ DIEDW 81_ SCCPT 86_ PWTSF 91_ QSSCY 96_ FISTG 101_ MQSWT 106_ KSQKN 111_ CSVMG 116_ ADLVV 121_ INTRE 126_ EQDFI 131_ IQNLK 136_ RNSSY 141_ FLGLS 146_ DPGGR 151_ RHWQW 156_ VDQTP 161_ YNENV 166_ TFWHS 171_ GEPNN 176_ LDERC 181_ AIINF 186_ RSSEE 191_ WGWND 196_ IHCHV 201_ PQKSI 206_CKMKK
1: Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283)