Protein DDI1 homolog 1 (EC 3.4.23.-)
1_MLITV 6_ YCVRR 11_ DLSEV 16_ TFSLQ 21_ VSPDF 26_ ELRNF 31_ KVLCE 36_ AESRV 41_ PVEEI 46_ QIIHM 51_ ERLLI 56_ EDHCS 61_ LGSYG 66_ LKDGD 71_ IVVLL 76_ QKDNV 81_ GPRAP 86_ GRAPN 91_ QPRVD 96_ FSGIA 101_ VPGTS 106_ SSRPQ 111_ HPGQQ 116_ QQRTP 121_ AAQRS 126_ QGLAS 131_ GEKVA 136_ GLQGL 141_ GSPAL 146_ IRSML 151_ LSNPH 156_ DLSLL 161_ KERNP 166_ PLAEA 171_ LLSGS 176_ LETFS 181_ QVLME 186_ QQREK 191_ ALREQ 196_ ERLRL 201_ YTADP 206_ LDREA 211_ QAKIE 216_ EEIRQ 221_ QNIEE 226_ NMNIA 231_ IEEAP 236_ ESFGQ 241_ VTMLY 246_ INCKV 251_ NGHPL 256_ KAFVD 261_ SGAQM 266_ TIMSQ 271_ ACAER 276_ CNIMR 281_ LVDRR 286_ WAGVA 291_ KGVGT 296_ QRIIG 301_ RVHLA 306_ QIQIE 311_ GDFLQ 316_ CSFSI 321_ LEDQP 326_ MDMLL 331_ GLDML 336_ RRHQC 341_ SIDLK 346_ KNVLV 351_ IGTTG 356_ TQTYF 361_ LPEGE 366_ LPLCS 371_ RMVSG 376_ QDESS 381_ DKEIT 386_ HSVMD 391_SGRKE
1: Probable aspartic protease (Probable). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612)