Cytosolic arginine sensor for mTORC1 subunit 1 (Cellular arginine sensor for mTORC1 protein 1) (GATS-like protein 3)
1_MELHI 6_ LEHRV 11_ RVLSV 16_ ARPGL 21_ WLYTH 26_ PLIKL 31_ LFLPR 36_ RSRCK 41_ FFSLT 46_ ETPED 51_ YTLMV 56_ DEEGF 61_ KELPP 66_ SEFLQ 71_ VAEAT 76_ WLVLN 81_ VSSHS 86_ GAAVQ 91_ AAGVT 96_ KIARS 101_ VIAPL 106_ AEHHV 111_ SVLML 116_ STYQT 121_ DFILV 126_ REQDL 131_ SVVIH 136_ TLAQE 141_ FDIYR 146_ EVGGE 151_ PVPVT 156_ RDDSS 161_ NGFPR 166_ TQHGP 171_ SPTVH 176_ PIQSP 181_ QNRFC 186_ VLTLD 191_ PETLP 196_ AIATT 201_ LIDVL 206_ FYSHS 211_ TPKEA 216_ ASSSP 221_ EPSSI 226_ TFFAF 231_ SLIEG 236_ YISIV 241_ MDAET 246_ QKKFP 251_ SDLLL 256_ TSSSG 261_ ELWRM 266_ VRIGG 271_ QPLGF 276_ DECGI 281_ VAQIA 286_ GPLAA 291_ ADISA 296_ YYIST 301_ FNFDH 306_ ALVPE 311_ DGIGS 316_ VIEVL 321_QRRQE
1: Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:26972053, PubMed:27487210, PubMed:33594058). As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1 (PubMed:26972053, PubMed:27487210, PubMed:33594058). Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway (PubMed:26972053, PubMed:27487210, PubMed:33594058)