E3 ubiquitin-protein ligase RNF139 (EC 2.3.2.27) (RING finger protein 139) (RING-type E3 ubiquitin transferase RNF139) (Translocation in renal carcinoma on chromosome 8 protein)
1_MAAVG 6_ PPQQQ 11_ VRMAH 16_ QQVWA 21_ ALEVA 26_ LRVPC 31_ LYIID 36_ AIFNS 41_ YPDSS 46_ QSRFC 51_ IVLQI 56_ FLRLF 61_ GVFAS 66_ SIVLI 71_ LSQRS 76_ LFKFY 81_ TYSSA 86_ FLLAA 91_ TSVLV 96_ NYYAS 101_ LHIDF 106_ YGAYN 111_ TSAFG 116_ IELLP 121_ RKGPS 126_ LWMAL 131_ IVLQL 136_ TFGIG 141_ YVTLL 146_ QIHSI 151_ YSQLI 156_ ILDLL 161_ VPVIG 166_ LITEL 171_ PLHIR 176_ ETLLF 181_ TSSLI 186_ LTLNT 191_ VFVLA 196_ VKLKW 201_ FYYST 206_ RYVYL 211_ LVRHM 216_ YRIYG 221_ LQLLM 226_ EDTWK 231_ RIRFP 236_ DILRV 241_ FWLTR 246_ VTAQA 251_ TVLMY 256_ ILRMA 261_ NETDS 266_ FFISW 271_ DDFWD 276_ LICNL 281_ IISGC 286_ DSTLT 291_ VLGMS 296_ AVISS 301_ VAHYL 306_ GLGIL 311_ AFIGS 316_ TEEDD 321_ RRLGF 326_ VAPVL 331_ FFILA 336_ LQTGL 341_ SGLRP 346_ EERLI 351_ RLSRN 356_ MCLLL 361_ TAVLH 366_ FIHGM 371_ TDPVL 376_ MSLSA 381_ SHVSS 386_ FRRHF 391_ PVLFV 396_ SACLF 401_ ILPVL 406_ LSYVL 411_ WHHYA 416_ LNTWL 421_ FAVTA 426_ FCVEL 431_ CLKVI 436_ VSLTV 441_ YTLFM 446_ IDGYY 451_ NVLWE 456_ KLDDY 461_ VYYVR 466_ STGSI 471_ IEFIF 476_ GVVMF 481_ GNGAY 486_ TMMFE 491_ SGSKI 496_ RAFMM 501_ CLHAY 506_ FNIYL 511_ QAKNG 516_ WKTFM 521_ NRRTA 526_ VKKIN 531_ SLPEI 536_ KGSRL 541_ QEIND 546_ VCAIC 551_ YHEFT 556_ TSARI 561_ TPCNH 566_ YFHAL 571_ CLRKW 576_ LYIQD 581_ TCPMC 586_ HQKVY 591_ IEDDI 596_ KDNSN 601_ VSNNN 606_ GFIPP 611_ NETPE 616_ EAVRE 621_ AAAES 626_ DRELN 631_ EDDST 636_ DCDDD 641_ VQRER 646_ NGVIQ 651_ HTGAA 656_AEEFN
1: E3-ubiquitin ligase; acts as a negative regulator of cell proliferation through mechanisms involving G2/M arrest and cell death (PubMed:10500182, PubMed:12032852, PubMed:17016439). Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER) (PubMed:19720873). Affects SREBP processing by hindering the SREBP-SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression (PubMed:19706601, PubMed:20068067). Involved in the sterol-accelerated degradation of HMGCR (PubMed:22143767, PubMed:23223569). This is achieved through binding of RNF139 to INSIG1 and/or INSIG2 at the ER membrane (PubMed:22143767). In addition, interaction of RNF139 with AUP1 facilitates interaction of RNF139 with ubiquitin-conjugating enzyme UBE2G2 and ubiquitin ligase AMFR, leading to ubiquitination of HMGCR (PubMed:23223569). The ubiquitinated HMGCR is then released from the ER into the cytosol for subsequent destruction (PubMed:22143767, PubMed:23223569). Required for INSIG1 ubiquitination (PubMed:20068067). May be required for EIF3 complex ubiquitination (PubMed:20068067)