Marginal zone B- and B1-cell-specific protein (Mesenteric estrogen-dependent adipose 7) (MEDA-7) (Plasma cell-induced resident endoplasmic reticulum protein) (Plasma cell-induced resident ER protein) (pERp1) (Proapoptotic caspase adapter protein)
1_MRLSL 6_ PLLLL 11_ LLGAW 16_ AIPGG 21_ LGDRA 26_ PLTAT 31_ APQLD 36_ DEEMY 41_ SAHMP 46_ AHLRC 51_ DACRA 56_ VAYQM 61_ WQNLA 66_ KAETK 71_ LHTSN 76_ SGGRR 81_ ELSEL 86_ VYTDV 91_ LDRSC 96_ SRNWQ 101_ DYGVR 106_ EVDQV 111_ KRLTG 116_ PGLSE 121_ GPEPS 126_ ISVMV 131_ TGGPW 136_ PTRLS 141_ RTCLH 146_ YLGEF 151_ GEDQI 156_ YEAHQ 161_ QGRGA 166_ LEALL 171_ CGGPQ 176_ GACSE 181_KVSAT
1: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation
2: Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance