Splicing factor U2AF 26 kDa subunit (U2 auxiliary factor 26) (U2 small nuclear RNA auxiliary factor 1-like protein 4) (U2AF1-like 4) (U2(RNU2) small nuclear RNA auxiliary factor 1-like protein 3) (U2 small nuclear RNA auxiliary factor 1-like protein 3) (U2AF1-like protein 3)
1_MAEYL 6_ ASIFG 11_ TEKDK 16_ VNCSF 21_ YFKIG 26_ VCRHG 31_ DRCSR 36_ LHNKP 41_ TFSQT 46_ IVLLN 51_ LYRNP 56_ QNTAQ 61_ TADGS 66_ HCHVS 71_ DVEVQ 76_ EHYDS 81_ FFEEV 86_ FTELQ 91_ EKYGE 96_ IEEMN 101_ VCDNL 106_ GDHLV 111_ GNVYV 116_ KFRRE 121_ EDGER 126_ AVAEL 131_ SNRWF 136_ NGQAV 141_ HGELS 146_ PVTDF 151_ RESCC 156_ RQYEM 161_ GECTR 166_ GGFCN 171_ FMHLR 176_ PISQN 181_ LQRQL 186_ YGRGP 191_ RRRSP 196_ PRFHT 201_ GHHPR 206_ ERNHR 211_CSPDH
1: RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). Shows a preference for AGC or AGA (By similarity)