PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135)
1_MAAAA 6_ GPGAA 11_ LSPRP 16_ CDSDP 21_ ATPGA 26_ QSPKD 31_ DNEDN 36_ SNDGT 41_ QPSKR 46_ RRMGS 51_ GDSSR 56_ SCETS 61_ SQDLG 66_ FSYYP 71_ AENLI 76_ EYKWP 81_ PDETG 86_ EYYML 91_ QEQVS 96_ EYLGV 101_ TSFKR 106_ KYPDL 111_ ERRDL 116_ SHKEK 121_ LYLRE 126_ LNVIT 131_ ETQCT 136_ LGLTA 141_ LRSDE 146_ VIDLM 151_ IKEYP 156_ AKHAE 161_ YSVIL 166_ QEKER 171_ QRITD 176_ HYKEY 181_ SQMQQ 186_ QNTQK 191_ VEASK 196_ VPEYI 201_ KKAAK 206_ KAAEF 211_ NSNLN 216_ RERME 221_ ERRAY 226_ FDLQT 231_ HVIQV 236_ PQGKY 241_ KVLPT 246_ ERTKV 251_ SSYPV 256_ ALIPG 261_ QFQEY 266_ YKRYS 271_ PDELR 276_ YLPLN 281_ TALYE 286_ PPLDP 291_ ELPAL 296_ DSDGD 301_ SDDGE 306_ DGRGD 311_ EKRKN 316_ KGTSD 321_ SSSGN 326_ VSEGE 331_ SPPDS 336_ QEDSF 341_ QGRQK 346_ SKDKA 351_ ATPRK 356_ DGPKR 361_ SVLSK 366_ SVPGY 371_ KPKVI 376_ PNAIC 381_ GICLK 386_ GKESN 391_ KKGKA 396_ ESLIH 401_ CSQCE 406_ NSGHP 411_ SCLDM 416_ TMELV 421_ SMIKT 426_ YPWQC 431_ MECKT 436_ CIICG 441_ QPHHE 446_ EEMMF 451_ CDMCD 456_ RGYHT 461_ FCVGL 466_ GAIPS 471_ GRWIC 476_ DCCQR 481_ APPTP 486_ RKVGR 491_RGKNS
1: Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity)