Ras-related protein Rab-2B (EC 3.6.5.2)
1_MTYAY 6_ LFKYI 11_ IIGDT 16_ GVGKS 21_ CLLLQ 26_ FTDKR 31_ FQPVH 36_ DLTIG 41_ VEFGA 46_ RMVNI 51_ DGKQI 56_ KLQIW 61_ DTAGQ 66_ ESFRS 71_ ITRSY 76_ YRGAA 81_ GALLV 86_ YDITR 91_ RETFN 96_ HLTSW 101_ LEDAR 106_ QHSSS 111_ NMVIM 116_ LIGNK 121_ SDLES 126_ RRDVK 131_ REEGE 136_ AFARE 141_ HGLIF 146_ METSA 151_ KTACN 156_ VEEAF 161_ INTAK 166_ EIYRK 171_ IQQGL 176_ FDVHN 181_ EANGI 186_ KIGPQ 191_ QSIST 196_ SVGPS 201_ ASQRN 206_ SRDIG 211_SNSGC
1: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28483915)