Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1)
1_MMSIK 6_ AFTLV 11_ SAVER 16_ ELLMG 21_ DKERV 26_ NIECV 31_ ECCGR 36_ DLYVG 41_ TNDCF 46_ VYHFL 51_ LEERP 56_ VPAGP 61_ ATFTA 66_ TKQLQ 71_ RHLGF 76_ KKPVN 81_ ELRAA 86_ SALNR 91_ LLVLC 96_ DNSIS 101_ LVNML 106_ NLEPV 111_ PSGAR 116_ IKGAA 121_ TFALN 126_ ENPVS 131_ GDPFC 136_ VEVCI 141_ ISVKR 146_ RTIQM 151_ FLVYE 156_ DRVQI 161_ VKEVS 166_ TAEQP 171_ LAVAV 176_ DGHFL 181_ CLALT 186_ TQYII 191_ HNYST 196_ GVSQD 201_ LFPYC 206_ SEERP 211_ PIVKR 216_ IGRQE 221_ FLLAG 226_ PGGLG 231_ MFATV 236_ AGISQ 241_ RAPVH 246_ WSENV 251_ IGAAV 256_ SFPYV 261_ IALDD 266_ EFITV 271_ HSMLD 276_ QQQKQ 281_ TLPFK 286_ EGHIL 291_ QDFEG 296_ RVIVA 301_ TSKGV 306_ YILVP 311_ LPLEK 316_ QIQDL 321_ LASRR 326_ VEEAL 331_ VLAKG 336_ ARRNI 341_ PKEKF 346_ QVMYR 351_ RILQQ 356_ AGFIQ 361_ FAQLQ 366_ FLEAK 371_ ELFRS 376_ GQLDV 381_ RELIS 386_ LYPFL 391_ LPTSS 396_ SFTRS 401_ HPPLH 406_ EYADL 411_ NQLTQ 416_ GDQEK 421_ MAKCK 426_ RFLMS 431_ YLNEV 436_ RSTEV 441_ ANGYK 446_ EDIDT 451_ ALLKL 456_ YAEAD 461_ HDSLL 466_ DLLVT 471_ ENFCL 476_ LTDSA 481_ AWLEK 486_ HKKYF 491_ ALGLL 496_ YHYNN 501_ QDAAA 506_ VQLWV 511_ NIVNG 516_ DVQDS 521_ TRSDL 526_ YEYIV 531_ DFLTY 536_ CLDEE 541_ LVWAY 546_ ADWVL 551_ QKSEE 556_ VGVQV 561_ FTKRP 566_ LDEQQ 571_ KNSFN 576_ PDDII 581_ NCLKK 586_ YPKAL 591_ VKYLE 596_ HLVID 601_ KRLQK 606_ EEYHT 611_ HLAVL 616_ YLEEV 621_ LLQRA 626_ SASGK 631_ GAEAT 636_ ETQAK 641_ LRRLL 646_ QKSDL 651_ YRVHF 656_ LLERL 661_ QGAGL 666_ PMESA 671_ ILHGK 676_ LGEHE 681_ KALHI 686_ LVHEL 691_ QDFAA 696_ AEDYC 701_ LWCSE 706_ GRDPP 711_ HRQQL 716_ FHTLL 721_ AIYLH 726_ AGPTA 731_ HELAV 736_ AAVDL 741_ LNRHA 746_ TEFDA 751_ AQVLQ 756_ MLPDT 761_ WSVQL 766_ LCPFL 771_ MGAMR 776_ DSIHA 781_ RRTMQ 786_ VALGL 791_ ARSEN 796_ LIYTY 801_ DKMKL 806_ KGSSI 811_ QLSDK 816_ KLCQI 821_ CQNPF 826_ CEPVF 831_ VRYPN 836_ GGLVH 841_ THCAA 846_ SRHTN 851_PSSSS
1: Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2
2: Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (PubMed:25266290)