Histone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a)
1_MDLRV 6_ GQRPP 11_ VEPPP 16_ EPTLL 21_ ALQRP 26_ QRLHH 31_ HLFLA 36_ GLQQQ 41_ RSVEP 46_ MRLSM 51_ DTPMP 56_ ELQVG 61_ PQEQE 66_ LRQLL 71_ HKDKS 76_ KRSAV 81_ ASSVV 86_ KQKLA 91_ EVILK 96_ KQQAA 101_ LERTV 106_ HPNSP 111_ GIPYR 116_ TLEPL 121_ ETEGA 126_ TRSML 131_ SSFLP 136_ PVPSL 141_ PSDPP 146_ EHFPL 151_ RKTVS 156_ EPNLK 161_ LRYKP 166_ KKSLE 171_ RRKNP 176_ LLRKE 181_ SAPPS 186_ LRRRP 191_ AETLG 196_ DSSPS 201_ SSSTP 206_ ASGCS 211_ SPNDS 216_ EHGPN 221_ PILGS 226_ EALLG 231_ QRLRL 236_ QETSV 241_ APFAL 246_ PTVSL 251_ LPAIT 256_ LGLPA 261_ PARAD 266_ SDRRT 271_ HPTLG 276_ PRGPI 281_ LGSPH 286_ TPLFL 291_ PHGLE 296_ PEAGG 301_ TLPSR 306_ LQPIL 311_ LLDPS 316_ GSHAP 321_ LLTVP 326_ GLGPL 331_ PFHFA 336_ QSLMT 341_ TERLS 346_ GSGLH 351_ WPLSR 356_ TRSEP 361_ LPPSA 366_ TAPPP 371_ PGPMQ 376_ PRLEQ 381_ LKTHV 386_ QVIKR 391_ SAKPS 396_ EKPRL 401_ RQIPS 406_ AEDLE 411_ TDGGG 416_ PGQVV 421_ DDGLE 426_ HRELG 431_ HGQPE 436_ ARGPA 441_ PLQQH 446_ PQVLL 451_ WEQQR 456_ LAGRL 461_ PRGST 466_ GDTVL 471_ LPLAQ 476_ GGHRP 481_ LSRAQ 486_ SSPAA 491_ PASLS 496_ APEPA 501_ SQARV 506_ LSSSE 511_ TPART 516_ LPFTT 521_ GLIYD 526_ SVMLK 531_ HQCSC 536_ GDNSR 541_ HPEHA 546_ GRIQS 551_ IWSRL 556_ QERGL 561_ RSQCE 566_ CLRGR 571_ KASLE 576_ ELQSV 581_ HSERH 586_ VLLYG 591_ TNPLS 596_ RLKLD 601_ NGKLA 606_ GLLAQ 611_ RMFVM 616_ LPCGG 621_ VGVDT 626_ DTIWN 631_ ELHSS 636_ NAARW 641_ AAGSV 646_ TDLAF 651_ KVASR 656_ ELKNG 661_ FAVVR 666_ PPGHH 671_ ADHST 676_ AMGFC 681_ FFNSV 686_ AIACR 691_ QLQQQ 696_ SKASK 701_ ILIVD 706_ WDVHH 711_ GNGTQ 716_ QTFYQ 721_ DPSVL 726_ YISLH 731_ RHDDG 736_ NFFPG 741_ SGAVD 746_ EVGAG 751_ SGEGF 756_ NVNVA 761_ WAGGL 766_ DPPMG 771_ DPEYL 776_ AAFRI 781_ VVMPI 786_ AREFS 791_ PDLVL 796_ VSAGF 801_ DAAEG 806_ HPAPL 811_ GGYHV 816_ SAKCF 821_ GYMTQ 826_ QLMNL 831_ AGGAV 836_ VLALE 841_ GGHDL 846_ TAICD 851_ ASEAC 856_ VAALL 861_ GNRVD 866_ PLSEE 871_ GWKQK 876_ PNLNA 881_ IRSLE 886_ AVIRV 891_ HSKYW 896_ GCMQR 901_ LASCP 906_ DSWVP 911_ RVPGA 916_ DKEEV 921_ EAVTA 926_ LASLS 931_ VGILA 936_ EDRPS 941_ EQLVE 946_EEEPM
1: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679)