Serine/threonine/tyrosine-interacting protein (Inactive tyrosine-protein phosphatase STYX) (Phosphoserine/threonine/tyrosine interaction protein)
1_MEDVK 6_ LEFPS 11_ LPQCK 16_ EDAEE 21_ WTYPM 26_ RREMQ 31_ EILPG 36_ LFLGP 41_ YSSAM 46_ KSKLP 51_ VLQKH 56_ GITHI 61_ ICIRQ 66_ NIEAN 71_ FIKPN 76_ FQQLF 81_ RYLVL 86_ DIADN 91_ PVENI 96_ IRFFP 101_ MTKEF 106_ IDGSL 111_ QMGGK 116_ VLVHG 121_ NAGIS 126_ RSAAF 131_ VIAYI 136_ METFG 141_ MKYRD 146_ AFAYV 151_ QERRF 156_ CINPN 161_ AGFVH 166_ QLQEY 171_ EAIYL 176_ AKLTI 181_ QMMSP 186_ LQIER 191_ SLSVH 196_ SGTTG 201_ SLKRT 206_ HEEED 211_ DFGTM 216_QVATA
1: Catalytically inactive phosphatase (PubMed:23847209). Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2) (PubMed:23847209). By binding to the F-box of FBXW7, prevents the assembly of FBXW7 into the SCF E3 ubiquitin-protein ligase complex, and thereby inhibits degradation of its substrates (PubMed:28007894). Plays a role in spermatogenesis (By similarity)